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As part of a general investigation on the effects of blood flow patterns in sidewall aneurysm, in vitro steady flow studies on rigid aneurysm models have been conducted using Particle Image Velocimetry over a range of Reynolds number from 200 to 1600. Above Reynolds number 700, one large recirculating vortex would be formed, occupying the entire aneurysmal(More)
The goal of this study was to investigate the possible therapy mechanism of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. Leaf (TAL) in alveolar macrophage (AM) of chronic bronchitis (CB) rats. CB model was established by injection of bacillus calmette guein (BCG) plus lipopolisacharide (LPS) in rats. TAL significantly inhibited the increased NO(More)
The effects of impeller geometry on the performance of a centrifugal blood pump model [the MSCBP design of Akamatsu and Tsukiya (The Seventh Asian Congress of Fluid Mechanics (1997), 7-10) at a 1:1 scale] have been investigated both experimentally and computationally. Four impeller designs were tested for pump hydraulic performance at the operating point(More)
Fluid dynamic forces in centrifugal blood pump impellers are of key importance in destruction of red blood cells (RBCs) because high rotational speed leads to strong interaction between the impeller and the RBCs. In this paper, three-dimensional models of five different blade geometries are investigated numerically using the commercial software(More)
This article presents computational studies on the effects of inlet guide vanes (IGVs) on the flow pattern and shear stress in a centrifugal blood pump. The effect of IGVs is to introduce a pre-swirl to fluid particles entering the impeller with the intention that the fluid particles will travel along the blade profile. Currently, most commercial(More)
The relative flow field within the impeller passage of a centrifugal blood pump had been examined using flow visualization technique and computational fluid dynamics. It was found that for a seven-blade radial impeller design, the required flow rate and static pressure rise across the pump could be achieved but the flow field within the blades was highly(More)
Steady and pulsatile flow characteristics in rigid abdominal aortic aneurysm (AAA) models were investigated computationally (using Fluent v. 4.3) over a range of Reynolds number (from 200 to 1600) and Womersley number (from 17 to 22). Some comparisons with measurements obtained by particle image velocimetry under the pulsatile flow conditions are also(More)
The flow characteristics and the corresponding hydrodynamic stability in an idealized asymmetric abdominal aortic aneurysm (AAA) model have been investigated using a laser Doppler anemometer. A rectified sine waveform was used to simulate aortic flow conditions (Re(delta) = 806 and alpha = 12.2). The flow around the distal neck of the AAA model undergoes(More)
Longitudinal and transverse velocity increments are measured both temporally and spatially using two X-wire probes in the intermediate region of a cylinder wake over Taylor microscale Reynolds numbers in the range of 100-300. The scaling exponents of both the spatial and temporal longitudinal velocity increments agree favorably with the predictions of(More)
Mutations in mitochondrial tRNA (mt-tRNA) genes have been found to be associated with various diseases including lung cancer. To understand the possible relationship between mtRNA mutations and lung cancer, we sequenced the 22 mt-tRNA genes from 200 lung cancer blood samples, as well as 100 healthy subjects. As a result, five mutations were identified(More)