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We have identified two compounds that inhibit the expression of endothelial-leukocyte adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin. These compounds act by inhibiting tumor necrosis factor-alpha-induced phosphorylation of IkappaB-alpha, resulting in decreased nuclear factor-kappaB and decreased(More)
CBP (CREB-binding protein) and p300 are versatile coactivators that link transcriptional activators to the basal transcriptional apparatus. In the present study, we identify CBP and p300 as coactivators of the nuclear factor-kappaB (NF-kappaB) component p65 (RelA). Consistent with their role as coactivators, both CBP and p300 potentiated p65-activated(More)
Open Access Oral presentation OA06-04. The role of early T-cell responses in subjects with acute HIV-1 infection MK Liu*1, G Ferrari2, J Salazar3, B Keele3, RL Tanner1, P Hraber4, E Giorgi4, VV Ganusov4, GH Learn4, MG Salazar3, SR Moore1, K Digleria1, Z Yu1, T Rostron1, C DeBoer5, A Williams5, C Margaret5, J Kopycinski6, SL Campion1, VE Bourne1, S(More)
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