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Binding of peptide hormones to surface membrane receptors leads to the transcription of specific genes within relevant target cells. How these signals are transduced to alter gene expression is largely unknown, but this mechanism probably involves a sequence of enzymatic steps that activate factors in the nucleus that modulate transcription. We now(More)
The latent period of AIDS is influenced by factors which activate human immunodeficiency virus (HIV) replication in different cell types. Although monocytic cells may provide a reservoir for virus production in vivo, their regulation of HIV transcription has not been defined. We now report that HIV gene expression in the monocyte lineage is regulated by(More)
Cells of the monocyte-macrophage lineage are important targets of HIV infection. We report here that the phenotypic differentiation of monocyte cell lines induced by phorbol esters or tumour necrosis factor alpha (TNF alpha) is associated with expression of nuclear factor kappa B (NF-kappa B). In parallel with such differentiation, HIV transcription,(More)
Gene expression in eukaryotic cells can be altered in different ways by extracellular agents, including mitogens and cytokines. Such differential gene expression is mediated in part through the effects of these stimuli on distinct sets of cellular transcription factors. In this report, the effects of phorbol myristate acetate, tumor necrosis factor-alpha(More)
While initial investigations originally defined the biological activity of chemokines as proteins with novel chemotactic activity for specific subpopulations of leukocytes, data now supports a much broader biological role for the chemokines. The chemotactic activity provides the means for the accumulation of granulocytes at foci of acute inflammation, via(More)
While initial investigations originally defined the biological activity of chemokines as proteins with novel chemotactic activity for specific subpopulations of leukocytes, data now supports a much broader biological role for the chemokines. The chemotactic activity provides the means for the accumulation of granulocytes at foci of acute inflammation, via(More)
While initial investigations originally defined the biological activity of chemokines as proteins with novel chemotactic activity for specific subpopulations of leukocytes, data now supports a much broader biological role for the chemokines. The chemotactic activity provides the means for the accumulation of granulocytes at foci of acute inflammation, via(More)
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