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OBJECTIVE Chronic migraine (CM) is a prevalent and disabling neurological disorder. Phase III REsearch Evaluating Migraine Prophylaxis Therapy (PREEMPT) clinical program assessed efficacy and safety of onabotulinumtoxinA (BOTOX(®)) for prophylaxis of headaches in adults with CM. This secondary analysis assessed patients who received all five treatment(More)
OBJECTIVES Migraine aura is commonly considered to be a distinct phase of a migraine attack that precedes headache. The objective of the study was to examine a large number of prospectively recorded attacks of migraine with aura and determine the timing of headache and other migraine symptoms relative to aura. METHODS As part of a clinical trial we(More)
Methods PREEMPT (two phase 3 studies: 24-wk, double-blind, placebo-controlled [DBPC], parallel-group phase, followed by 32-wk, open-label phase) evaluated efficacy & safety of onabotulinumtoxinA in CM (≥15 days/month with headache lasting ≥4 hr/day). Patients were randomized (1:1) to onabotulinumtoxinA (O) or placebo (P) every 12 wks for 2 cycles, followed(More)
Menstrually related migraine (MRM) is defined as occurring from days -2 to +3 of menstruation in at least 2 out of 3 menstrual cycles, and additionally at other times of the menstrual cycle. MRM is generally longer lasting, more severe, and more difficult to treat compared to non-MRM attacks. MAP0004 is an investigational orally inhaled dihydroergotamine(More)
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