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OBJECTIVE In the general population, folic acid supplementation during pregnancy has been demonstrated to reduce the frequency of neural tube defects (NTDs) and other major congenital malformations (MCMs). It is recommended that women with epilepsy contemplating pregnancy take supplemental folic acid because of the known antifolate effect of some… (More)
OBJECTIVES Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The magnitude of this risk varies by AED exposure. Here we provide updated results from the UK Epilepsy and Pregnancy Register of the risk of MCMs after monotherapy exposure to valproate, carbamazepine and lamotrigine. METHODS… (More)
OBJECTIVE To assess the cardiovascular physical examination skills of emergency medicine (EM) housestaff and attending physicians. METHODS Prospective, cohort assessment of EM housestaff and faculty performance on 3 valvular abnormality simulations (mitral regurgitation, mitral stenosis, and aortic regurgitation) conducted on the cardiology patient… (More)
BACKGROUND Use of valproate in pregnancy, especially in doses over 1000mg a day, is known to be associated with a higher risk for major congenital malformations compared with other antiepileptic drugs. We sought to investigate whether the increased risk could be minimised by using controlled release or divided daily doses of valproate. METHODS The UK… (More)
Keynote address: " Marfan syndrome and related disorders: from gene to therapy " Prof. 3 AED Pregnancy register, UK and Ireland Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The risk magnitude varies by AED exposure. We provide results from the UK and Ireland Epilepsy and Pregnancy Registers,… (More)
Introduction: Platelet activation has a role in the pathogenesis of acute lung injury (ALI). Observational data suggests aspirin treatment may prevent the development of ALI in critically ill patients. However, it is unknown if aspirin usage alters outcomes in patients with established ALI.
Increased levetiracetam clearance in pregnancy: Is seizure frequency affected? Emerging data on the teratogenic potential of antiepileptic drugs (AEDs), in particular valproate, have resulted in a prescribing shift towards lamotrigine and levetiracetam in women of childbearing age with epilepsy. 1,2 Over the last 20 years prescription of lamotrigine to… (More)
Introduction: Sentinel Lymph Node Biopsy (SLNB) is set to become the standard of care for axillary staging in breast cancer. The aim of this study is to evaluate the tumour characteristics associated with false negative intraoperative imprint cytology.