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How nephrotoxic is carboplatin? Sir-The study by Sleijfer et al. (1989) reports on a significant deterioration in renal function following moderate dose carboplatin-with a 19% reduction in glomerular filtration rate. This raises reservations about the claimed advantages of carboplatin over cisplatin and suggests that not only is close monitoring of renal(More)
In a study designed to compare response rates of patients with stage III epithelial ovarian carcinoma to ifosfamide and carboplatin, 152 patients were randomised to receive either sequential therapy with three cycles of ifosfamide followed by three cycles of carboplatin, or to six cycles of single agent carboplatin. Ifosfamide was given every 3 weeks in a(More)
Carbohydrate antigen 19-9 (CA19-9) and carcino-embryonic antigen (CEA) have been well recognized as tumor markers for colorectal cancer. Previous studies suggested that obesity is inversely associated with the screening of CEA and CA19-9 levels and may reduce screening sensitivity. This study was conducted to evaluate the association of body mass index(More)
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