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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
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Differential Induction of the Toll-Like Receptor 4-MyD88-Dependent and -Independent Signaling Pathways by Endotoxins
TLDR
Neisseria meningitidis endotoxin was a potent agonist of both the MyD88-dependent and -independent signaling pathways of the TLR4 receptor complex of human macrophages and response was restored inTLR4-MD-2-transfected human embryonic kidney 293 cells.
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Cationic Antimicrobial Peptide Resistance in Neisseria meningitidis
TLDR
Data indicated that meningococci utilize multiple mechanisms including the action of the MtrC-MtrD- MtrE efflux pump and lipid A modification as well as the type IV pilin secretion system to modulate levels of CAMP resistance.
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A Melanin Pigment Purified from an Epidemic Strain of Burkholderia cepacia Attenuates Monocyte Respiratory Burst Activity by Scavenging Superoxide Anion
TLDR
It is concluded that melanin-producing B. cepacia may derive protection from the free-radical-scavenging properties of this pigment, and melanin inhibited•O2− detection when added at the triggering stage of the respiratory burst.
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Exploring the effect of image enhancement techniques on COVID-19 detection using chest X-ray images
View on Elsevier
Lipopolysaccharide (LPS) from Burkholderia cepacia Is More Active than LPS from Pseudomonas aeruginosa and Stenotrophomonas maltophilia in Stimulating Tumor Necrosis Factor Alpha from Human Monocytes
TLDR
Results suggest that B. cepacia LPS might play a role in the pathogenesis of inflammatory lung disease in cystic fibrosis, and in some patients it might be responsible, at least in part, for the sepsis-like cEPacia syndrome.
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Incidence of macrolide resistance in Streptococcus pneumoniae after introduction of the pneumococcal conjugate vaccine: population-based assessment
View on Elsevier
The role of vitamin D in regulating the iron-hepcidin-ferroportin axis in monocytes
View on PubMed
Neisseria meningitidis Lipooligosaccharide Structure-Dependent Activation of the Macrophage CD14/Toll-Like Receptor 4 Pathway
TLDR
KDO2 linked to meningococcal lipid A was structurally required for maximal activation of the human macrophage TLR4 pathway and indicates an important role for KDO-lipid A in endotoxin biologic activity.
View on ASMUSA
Antimicrobial peptides and endotoxin inhibit cytokine and nitric oxide release but amplify respiratory burst response in human and murine macrophages
TLDR
Although AMP inhibited cytokine and nitric oxide induction by endotoxin in a TLR4‐dependent manner, AMP and endotoxin amplified ROS release in a RL4‐independent manner possibly by exerting a prolonged catalytic effect on the ROS generating enzymes such as the NADPH‐oxidase complex.
View on Wiley
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