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Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis
- S. Zuckerman, J. Shellhaas, Larry D. Butter
- Biology, Medicine
- European journal of immunology
- 1 February 1989
In vitro data would suggest that the maintenance of elevated IL 1 levels coincident with the appearance of endogenous corticosteroids during LPS shock is related to the synthesis of IL 1 by both monocyte‐macrophages and non‐myeloid cell populations including endothelial cells. Expand
Interferon-gamma induces downregulation of Tangier disease gene (ATP-binding-cassette transporter 1) in macrophage-derived foam cells.
By decreasing cholesterol efflux through pathways that include the upregulation of ACAT and the downregulation of ABC1, IFN-gamma can shift the equilibrium between macrophages and foam cells and thus impact the progression of an atherosclerotic lesion. Expand
Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations
- I. McInnes, Nicole L. Byers, +10 authors P. Taylor
- Chemistry, Medicine
- Arthritis Research & Therapy
- 2 August 2019
Different JAKis modulated distinct cytokine pathways to varying degrees, and no agent potently or continuously inhibited an individual cytokine signaling pathway throughout the dosing interval. Expand
Interferon-&ggr;–Mediated Downregulation of Cholesterol Efflux and ABC1 Expression Is by the Stat1 Pathway
- Xue-qing Wang, C. Panousis, M. L. Alfaro, G. Evans, S. Zuckerman
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 May 2002
The pathway by which IFN-&ggr; inhibited ABC1 expression was investigated with signal transducers and activators of transcription (Stat1) knockout mice showed that Stat1 signaling is necessary and sufficient for the inhibitory effects of IFN; on cholesterol efflux andABC1 expression. Expand
Inhibition of LDL oxidation and myeloperoxidase dependent tyrosyl radical formation by the selective estrogen receptor modulator raloxifene (LY139481 HCL).
A potential protective role for raloxifene as an anti-oxidant in in vitro assays designed to evaluate oxidant mediated radical formation and tissue damage is demonstrated. Expand
Isolation of a Fusarium solani mutant reduced in cutinase activity and virulence.
- A. Dantzig, S. Zuckerman, M. M. Andonov-Roland
- Biology, Medicine
- Journal of bacteriology
- 1 November 1986
The data suggest that the Fusarium solani isolate T-8 synthesizes reduced quantities of a functional and immunoreactive cutinase enzyme and that cutin enzyme plays a critical role in infection. Expand
The human Burkitt lymphoma cell line Namalwa represents a homogenous cell system characterized by high levels of Toll-like receptor 9 and activation by CpG oligonucleotides.
- Martin Hénault, Linda N. Lee, G. Evans, S. Zuckerman
- Medicine, Biology
- Journal of immunological methods
- 1 May 2005
The results suggest that the Namalwa Burkitt lymphoma line may serve as a useful cell-based assay for the detection of novel TLR9 agonists as well as a model to further explore the regulation ofTLR9 expression and signaling. Expand
Endotoxin tolerance: in vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level.
The hyporesponsive state associated with endotoxin tolerance is characterized by transcriptional regulation of both TNF and IL-1 synthesis, which is consistent with a decrease in transcriptional activity by nuclear run-on assays for both cytokines and a reduced amount of the nuclear-associated transcription factor NF-KB. Expand
Differential expression of interleukin-1 and tumor necrosis factor in murine septic shock models.
Experiments with adrenalectomized mice suggest that the absence of serum TNF in the CLP model is in part due to the modulatory effects of endogenous corticosteroids, which are effective at preventing death in the endotoxin model and yet had no beneficial effect in antibiotic-treated CLP animals. Expand
Gamma interferon: a central mediator in atherosclerosis
This review will focus on gamma interferon's contribution to plaque pathology and will finally consider how current therapies, as exemplified by HMG CoA reductase inhibitors or statins, may impact this process beyond lipid lowering, in part by inhibiting IFN-γ dependent processes. Expand