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- Publications
- Influence
ASPP proteins specifically stimulate the apoptotic function of p53.
- Y. Samuels-Lev, D. J. O'Connor, +7 authors X. Lu
- Biology, Medicine
- Molecular cell
- 26 October 2001
We identified a family of proteins termed ASPP. ASPP1 is a protein homologous to 53BP2, the C-terminal half of ASPP2. ASPP proteins interact with p53 and specifically enhance p53-induced apoptosis… Expand
RB regulates the stability and the apoptotic function of p53 via MDM2.
- J. Hsieh, F. Chan, D. J. O'Connor, S. Mittnacht, S. Zhong, X. Lu
- Biology, Medicine
- Molecular cell
- 1 February 1999
The binding of RB to MDM2 is shown to be essential for RB to overcome both the antiapoptotic function of MDM2 and the MDM2-dependent degradation of p53. The RB-MDM2 interaction does not prevent MDM2… Expand
Mitogen- and Stress-activated Protein Kinase 1 Mediates Activation of Akt by Ultraviolet B Irradiation*
- M. Nomura, A. Kaji, +5 authors Z. Dong
- Medicine, Chemistry
- The Journal of Biological Chemistry
- 6 July 2001
In this study, we investigated the mechanism by which UVB irradiation activates Akt (also known as protein kinase B (PKB)) in mouse epidermal JB6 cells. Treatment with a phosphatidylinositol 3-kinase… Expand
Activation of JNK1, RSK2, and MSK1 Is Involved in Serine 112 Phosphorylation of Bad by Ultraviolet B Radiation*
- Qing-Bai She, W. Ma, S. Zhong, Z. Dong
- Biology, Medicine
- The Journal of Biological Chemistry
- 5 July 2002
The Bcl-2 family member Bad is a pro-apoptotic protein, and phosphorylation of Bad by cytokines and growth factors promotes cell survival in many cell types. Induction of apoptosis by UV radiation is… Expand
PTEN Represses RNA Polymerase III-Dependent Transcription by Targeting the TFIIIB Complex
- Annette Woiwode, S. A. Johnson, +4 authors D. Johnson
- Biology, Medicine
- Molecular and Cellular Biology
- 7 April 2008
ABSTRACT PTEN, a tumor suppressor whose function is frequently lost in human cancers, possesses a lipid phosphatase activity that represses phosphatidylinositol 3-kinase (PI3K) signaling, controlling… Expand
Signal Transduction Pathways Involved in Phosphorylation and Activation of p70S6K Following Exposure to UVA Irradiation*
- Y. Zhang, Z. Dong, +4 authors Zigang Dong
- Biology, Medicine
- The Journal of Biological Chemistry
- 15 June 2001
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream… Expand
Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A
- S. Zhong, H. Goto, M. Inagaki, Z. Dong
- Biology, Medicine
- Oncogene
- 14 August 2003
Trichostatin A (TSA), a histone deacetylase inhibitor, strongly increases acetylation of the N-terminal tails of histone H3. Many studies have correlated the function of TSA with the hyperacetylation… Expand
Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.
- M. M. Khan, T. Nomura, +7 authors S. Ishii
- Medicine
- Molecular cell
- 2001
Fusion of the promyelocytic leukemia (PML) protein to the retinoic acid receptor-alpha (RARalpha) generates the transforming protein of acute promyelocytic leukemias. PML appears to be involved in… Expand
Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock.
- E. Sánchez, J. L. Hu, S. Zhong, P. Shen, M. J. Greene, P. Housley
- Biology, Medicine
- Molecular endocrinology
- 1 April 1994
We have examined the effects of heat shock on glucocorticoid receptor (GR)-mediated gene transcription in an L929 cell line derivative (LMCAT2) stably transfected with the mouse mammary tumor… Expand
Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis*
- Y. Zhang, P. Mattjus, +7 authors Zigang Dong
- Biology, Medicine
- The Journal of Biological Chemistry
- 13 April 2001
The sphingomyelin-ceramide pathway is an evolutionarily conserved ubiquitous signal transduction system that regulates many cell functions including apoptosis. Sphingomyelin (SM) is hydrolyzed to… Expand