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- Publications
- Influence
Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond
- Xiaojuan Chai, S. Zeng, Wen Xie
- Biology, Medicine
- Expert opinion on drug metabolism & toxicology
- 18 February 2013
Introduction: ‘Orphan' nuclear receptors belong to the nuclear receptor (NR) superfamily of transcriptional factors. Binding of ligands to these receptors results in the recruitment of the… Expand
Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system.
- F. Hu, Saiping Jiang, Yong-Zhong Du, H. Yuan, Yi-qing Ye, S. Zeng
- Chemistry, Medicine
- Colloids and surfaces. B, Biointerfaces
- 10 November 2005
Nanostuctured lipid carriers (NLC) based on mixture of solid lipids with spatially incompatible liquid lipids are a new type of lipid nanoparticles, which offer the advantage of improved drug loading… Expand
Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells.
- H. Yuan, J. Miao, Yong-Zhong Du, Jian You, Fuqiang Hu, S. Zeng
- Chemistry, Medicine
- International journal of pharmaceutics
- 4 February 2008
The aim of this study was to investigate the cellular uptake of solid lipid nanoparticles (SLN) and cytotoxicity of its paclitaxel delivery system. The conjugate of octadecylamine-fluorescein… Expand
Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract.
- T. Chen, L. Li, X. Lu, H. Jiang, S. Zeng
- Chemistry, Medicine
- Journal of agricultural and food chemistry
- 24 January 2007
Chrysanthemum morifolium extract (CME) has the protective effect on cardiovascular diseases. Luteolin and apigenin are two major bioactive components in vivo when CME is orally administrated to… Expand
Recent advances and perspectives of nucleic acid detection for coronavirus
- M. Shen, Y. Zhou, +4 authors S. Cai
- Chemistry, Medicine
- Journal of Pharmaceutical Analysis
- 1 March 2020
Abstract
The recent pneumonia outbreak caused by a novel coronavirus (SARS-CoV-2) in Chinais posing a great threat to global public health. Therefore, rapid and a accurate identification of… Expand
Human pregnane X receptor and resistance to chemotherapy in prostate cancer.
- Yakun Chen, Yong Tang, Man-Tzu Wang, S. Zeng, D. Nie
- Biology, Medicine
- Cancer research
- 1 November 2007
Resistance to chemotherapy is a significant barrier to the effective management of prostate cancer. Human pregnane X receptor (hPXR), an orphan nuclear receptor known for its activation by many… Expand
Involvement of P‐glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin
Quercetin, kaempferol, and isorhamnetin were the most important flavonoid constituents in extracts from Ginkgo biloba leaves. Transport studies of Ginkgo flavonols were performed in Caco‐2 cell… Expand
Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel.
- F. Hu, Guo-Fei Ren, H. Yuan, Yong-Zhong Du, S. Zeng
- Chemistry, Medicine
- Colloids and surfaces. B, Biointerfaces
- 1 July 2006
Stearic acid grafted chitosan oligosaccharide (CSO-SA) with different degree of amino substitution (SD) was synthesized by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-mediated coupling… Expand
PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.
- Chunna Yu, Shanshan Ye, +5 authors S. Zeng
- Biology, Medicine
- Chemico-biological interactions
- 15 January 2009
Danshen (Radix Salvia miltiorrhiza) is a famous Traditional Chinese Medicine used widely for the treatment of coronary heart disease and cerebrovascular disease. Diterpenoid tanshinones including… Expand
Role of Catechol-O-Methyltransferase in the Disposition of Luteolin in Rats
- Z. Chen, Meng Chen, +4 authors Huidi Jiang
- Medicine, Chemistry
- Drug Metabolism and Disposition
- 1 April 2011
Luteolin is mainly metabolized by phase II enzymes in animals and humans with glucuronidation and sulfation as the two known metabolic pathways. Although methylation of luteolin was reported… Expand