S. Zeng

Publications359
h-index36
Citations5,881
Highly Influential Citations227
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Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond
Introduction: ‘Orphan' nuclear receptors belong to the nuclear receptor (NR) superfamily of transcriptional factors. Binding of ligands to these receptors results in the recruitment of the… Expand
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Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system.
Nanostuctured lipid carriers (NLC) based on mixture of solid lipids with spatially incompatible liquid lipids are a new type of lipid nanoparticles, which offer the advantage of improved drug loading… Expand
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Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells.
The aim of this study was to investigate the cellular uptake of solid lipid nanoparticles (SLN) and cytotoxicity of its paclitaxel delivery system. The conjugate of octadecylamine-fluorescein… Expand
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Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract.
Chrysanthemum morifolium extract (CME) has the protective effect on cardiovascular diseases. Luteolin and apigenin are two major bioactive components in vivo when CME is orally administrated to… Expand
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Recent advances and perspectives of nucleic acid detection for coronavirus
  • M. Shen, Y. Zhou, +4 authors S. Cai
  • Chemistry, Medicine
  • Journal of Pharmaceutical Analysis
  • 1 March 2020
Abstract The recent pneumonia outbreak caused by a novel coronavirus (SARS-CoV-2) in Chinais posing a great threat to global public health. Therefore, rapid and a accurate identification of… Expand
  • 122
  • 8
Human pregnane X receptor and resistance to chemotherapy in prostate cancer.
Resistance to chemotherapy is a significant barrier to the effective management of prostate cancer. Human pregnane X receptor (hPXR), an orphan nuclear receptor known for its activation by many… Expand
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Involvement of P‐glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin
Quercetin, kaempferol, and isorhamnetin were the most important flavonoid constituents in extracts from Ginkgo biloba leaves. Transport studies of Ginkgo flavonols were performed in Caco‐2 cell… Expand
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Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel.
Stearic acid grafted chitosan oligosaccharide (CSO-SA) with different degree of amino substitution (SD) was synthesized by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-mediated coupling… Expand
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PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.
Danshen (Radix Salvia miltiorrhiza) is a famous Traditional Chinese Medicine used widely for the treatment of coronary heart disease and cerebrovascular disease. Diterpenoid tanshinones including… Expand
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Role of Catechol-O-Methyltransferase in the Disposition of Luteolin in Rats
Luteolin is mainly metabolized by phase II enzymes in animals and humans with glucuronidation and sulfation as the two known metabolic pathways. Although methylation of luteolin was reported… Expand
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