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Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond
Introduction: ‘Orphan' nuclear receptors belong to the nuclear receptor (NR) superfamily of transcriptional factors. Binding of ligands to these receptors results in the recruitment of theExpand
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Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system.
Nanostuctured lipid carriers (NLC) based on mixture of solid lipids with spatially incompatible liquid lipids are a new type of lipid nanoparticles, which offer the advantage of improved drug loadingExpand
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Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells.
The aim of this study was to investigate the cellular uptake of solid lipid nanoparticles (SLN) and cytotoxicity of its paclitaxel delivery system. The conjugate of octadecylamine-fluoresceinExpand
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Recent advances and perspectives of nucleic acid detection for coronavirus
Abstract The recent pneumonia outbreak caused by a novel coronavirus (SARS-CoV-2) in Chinais posing a great threat to global public health. Therefore, rapid and a accurate identification ofExpand
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Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract.
Chrysanthemum morifolium extract (CME) has the protective effect on cardiovascular diseases. Luteolin and apigenin are two major bioactive components in vivo when CME is orally administrated toExpand
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Involvement of P‐glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin
Quercetin, kaempferol, and isorhamnetin were the most important flavonoid constituents in extracts from Ginkgo biloba leaves. Transport studies of Ginkgo flavonols were performed in Caco‐2 cellExpand
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Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel.
Stearic acid grafted chitosan oligosaccharide (CSO-SA) with different degree of amino substitution (SD) was synthesized by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-mediated couplingExpand
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PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.
Danshen (Radix Salvia miltiorrhiza) is a famous Traditional Chinese Medicine used widely for the treatment of coronary heart disease and cerebrovascular disease. Diterpenoid tanshinones includingExpand
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Role of Catechol-O-Methyltransferase in the Disposition of Luteolin in Rats
Luteolin is mainly metabolized by phase II enzymes in animals and humans with glucuronidation and sulfation as the two known metabolic pathways. Although methylation of luteolin was reportedExpand
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Studies on oral absorption of stearic acid SLN by a novel fluorometric method.
In this study, the fluorescein isothiocyanate (FITC) labeled otcadecylamine (ODA), otcadecylamine-fluorescein isothiocyanate (ODA-FITC), was synthesized and used as a fluorescence marker to beExpand
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