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Choline: critical role during fetal development and dietary requirements in adults.
  • S. Zeisel
  • Biology, Medicine
  • Annual review of nutrition
  • 18 July 2006
When deprived of dietary choline, most men and postmenopausal women developed signs of organ dysfunction (fatty liver or muscle damage), while less than half of premenopausalWomen developed such signs. Expand
Choline and human nutrition.
It is believed that the normal human diet provides sufficient choline to sustain healthy organ function, however, vulnerable populations may become choline deficient, including the growing infant, the pregnant or lactating woman, the cirrhotic, and the patient fed intravenously. Expand
Concentrations of choline-containing compounds and betaine in common foods.
The choline concentration of 145 common foods was analyzed using liquid chromatography-mass spectrometry to examine the relationship between dietary folic acid and cancer or heart disease and betaine, a choline derivative, was examined. Expand
Choline: an essential nutrient for public health.
Given the importance of choline in a wide range of critical functions in the human body, coupled with less-than-optimal intakes among the population, dietary guidance should be developed to encourage the intake of ch Caroline-rich foods. Expand
Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline.
As the authors consider dietary requirements and possible effects on DNA methylation, it is important to realize that methionine, methyl-THF and choline can be fungible sources of methyl groups, and the design of studies should reflect this. Expand
Choline and choline esters in human and rat milk and in infant formulas.
Although the free choline moiety is adequately provided by infant formulas and bovine milk, reevaluation of the concentrations of other choline esters, in particular glycerophosphocholine and phosphocholine, may be warranted. Expand
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression
Choline influences liver function, and the dietary requirement for this nutrient varies depending on an individual's genotype and estrogen status, which is important for gastroenterologists seeking to understand why some individuals develop NAFLD and others do not, and why some patients tolerate total parenteral nutrition and others develop liver dysfunction. Expand
Choline, phosphatidylcholine and sphingomyelin in human and bovine milk and infant formulas.
The major choline-containing compounds of human milk (unesterified choline, phosphatidylcholine, sphingomyelin) were measured in samples obtained from mothers of full-term infants to show no consistent diurnal pattern of variation in milk concentrations. Expand
Maternal nutrition at conception modulates DNA methylation of human metastable epialleles
It is shown that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers, and several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Expand
Choline, an essential nutrient for humans.
Choline is required to make essential membrane phospholipids. It is a precursor for the biosynthesis of the neurotransmitter acetylcholine and also is an important source of labile methyl groups.Expand