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Electrospray ionization and tandem mass spectrometry of eicosanoids.
Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils*
The results strongly implicate MBOAT5 and MBOat7 in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils. Expand
Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis.
It is demonstrated that rhAPC reduces both endotoxin-induced accumulation of leukocytes in the airspaces and neutrophil chemotaxis, which may represent a mechanism by which rh APC improves survival in patients with sepsis. Expand
Leukotrienes: lipid bioeffectors of inflammatory reactions.
These potent lipid bioeffectors are synthesized during the course of inflammatory reactions and their pharmacological modulation is able to significantly attenuate the clinical manifestations associated with different inflammatory pathologies. Expand
Pulmonary Surfactant Phosphatidylglycerol Inhibits Mycoplasma pneumoniae-stimulated Eicosanoid Production from Human and Mouse Macrophages*
These data demonstrate that M. pneumoniae stimulates the production of eicosanoids from macrophages through TLR2, and POPG suppresses this pathogen-induced response. Expand
Release of Leukotriene A4 Versus Leukotriene B4 from Human Polymorphonuclear Leukocytes*
The objective of this study was to determine the relative amount of leukotriene A4 synthesized by human polymorphonuclear leukocytes (PMNL) that is available for transcellular biosynthetic processes, and it was demonstrated that in human PMNL, the relative amounts of nonenzymatic versus enzymatic leuko A4-derived metabolites increased with decreasing cell concentrations. Expand
Mast Cells, FcεRI, and IL-13 Are Required for Development of Airway Hyperresponsiveness after Aerosolized Allergen Exposure in the Absence of Adjuvant1
Results show that FcεRI is important for the development of AHR after an aerosolized allergen sensitization protocol and that this effect is mediated through Fc�RI on mast cells and production of IL-13 in the lung. Expand
Cysteinyl‐leukotriene receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl leukotrienes
The hypothesis that neutrophil and endothelial cells cooperate toward the local synthesis of cysLT within the brain vasculature and, acting via the cys LT2 receptor on endothelial Cells, may represent a contributing pathogenic mechanism in the development of cerebral inflammation and edema is supported. Expand
Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation
Transcellular cysLT synthesis during zymosan-induced peritonitis is examined, using bone marrow transplants with transgenic mice deficient in key enzymes of LT synthesis and analyzing all eicosanoids by liquid chromatography/tandem mass spectrometry to highlight the potential relevance of transcellular exchange of LTA4 for the synthesis of LTs mediating biological activities during inflammatory events in vivo. Expand
The role of PGE2 in intestinal inflammation and tumorigenesis.
The importance of the balance of prostaglandins produced in the intestinal tract for maintaining intestinal homeostasis and impacting tumor development is demonstrated. Expand