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Drug-resistant tuberculosis, clinical virulence, and the dominance of the Beijing strain family in Russia.
CONTEXT Tuberculosis and multidrug-resistant tuberculosis is a serious public health problem in Russia. OBJECTIVE To address the extent of "Beijing strain" transmission in the prison/civil sectorsExpand
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An Integrated Approach to Rapid Diagnosis of Tuberculosis and Multidrug Resistance Using Liquid Culture and Molecular Methods in Russia
Objective To analyse the feasibility, cost and performance of rapid tuberculosis (TB) molecular and culture systems, in a high multidrug-resistant TB (MDR TB) middle-income region (Samara, Russia)Expand
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A Structural Model of the Membrane‐Bound Aromatic Prenyltransferase UbiA from E. coli
The membrane‐bound enzyme 4‐hydroxybenzoic acid oligoprenyltransferase (ubiA) from E. coli is crucial for the production of ubiquinone, the essential electron carrier in prokaryotic and eukaryoticExpand
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Molecular and structural basis of metabolic diversity mediated by prenyldiphosphate converting enzymes.
General thermodynamic calculations using the semiempiric PM3 method have led to the conclusion that prenyldiphosphate converting enzymes require at least one divalent metal cation for the activationExpand
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Variability in interpretation of chest radiographs among Russian clinicians and implications for screening programmes: observational study
Abstract Objective To determine variability in interpretation of chest radiographs among tuberculosis specialists, radiologists, and respiratory specialists. Design Observational study. SettingExpand
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Increased risk of tuberculosis among health care workers in Samara Oblast, Russia: analysis of notification data.
SETTING Samara Oblast, Russia. OBJECTIVE To compare the rates of tuberculosis (TB) in health care workers (HCWs) working in TB services, general health services (GHS) and the general population inExpand
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Tuberculosis control in Samara Oblast, Russia: institutional and regulatory environment.
SETTING Tuberculosis control programme in Samara Oblast, Russia, funded in part by the government of the United Kingdom. OBJECTIVE To identify and evaluate institutional and regulatory influencesExpand
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The Directly Observed Therapy Short-Course (DOTS) strategy in Samara Oblast, Russian Federation
BackgroundThe World Health Organisation (WHO) defines Russia as one of the 22 highest-burden countries for tuberculosis (TB). The WHO Directly Observed Treatment Short Course (DOTS) strategyExpand
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Synthesis, inhibitory and activation properties of prenyldiphosphate mimics for aromatic prenylations with ubiA-prenyl transferase
Hydroxybenzoate oligoprenyl transferase from E. coli (ubiA-prenyl transferase) is a crucial enzyme for ubiquinone biosynthesis. It catalyzes the formation of 3-oligoprenyl-4-hydroxy- benzoates likeExpand
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