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An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.
Antimicrobial peptides are effector molecules of the innate immune system and contribute to host defense and regulation of inflammation. The human cathelicidin antimicrobial peptide LL-37/hCAP-18 isExpand
NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment.
Platelets, although not phagocytotic, have been suggested to release O. Since O-producing reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) oxidases can be specifically activated byExpand
Bid-induced release of AIF from mitochondria causes immediate neuronal cell death
Mitochondrial dysfunction and release of pro-apoptotic factors such as cytochrome c or apoptosis-inducing factor (AIF) from mitochondria are key features of neuronal cell death. The preciseExpand
Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets
Although tissue factor (TF), the principial initiator of physiological coagulation and pathological thrombosis, has recently been proposed to be present in human blood, the functional significanceExpand
Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass.
OBJECTIVE The occurrence of a systemic inflammatory reaction during cardiac surgery with cardiopulmonary bypass (CPB) has been well established, and the heart itself has been shown to releaseExpand
Tumor necrosis factor-alpha contributes to ischemia- and reperfusion-induced endothelial activation in isolated hearts.
-During myocardial reperfusion, polymorphonuclear neutrophil (PMN) adhesion involving the intercellular adhesion molecule-1 (ICAM-1) may lead to aggravation and prolongation of reperfusion injury. WeExpand
Nitric oxide enhances de novo formation of endothelial gap junctions.
OBJECTIVE Gap junctions (formed by connexins, Cx) are important for functional coordination of cells in the vascular wall. However, little is known about their physiological regulation in thisExpand
Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass.
OBJECTIVES The investigation centers on whether there is a reperfusion-induced specific cardiac inflammatory reaction after bypass surgery. BACKGROUND Cardiopulmonary bypass (CPB) leads to systemicExpand
Release of TNF-alpha during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers.
OBJECTIVES Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-alpha (TNF-alpha) and for activating TNF-alpha-converting enzyme (TACE). BACKGROUNDExpand
Cyclin-dependent Kinase 5 Regulates Endothelial Cell Migration and Angiogenesis
Angiogenesis contributes to various pathological conditions. Due to the resistance against existing antiangiogenic therapy, an urgent need exists to understand the molecular basis of vessel growthExpand