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Acetylcholinesterase inhibitors from Stephania venosa tuber
TLDR
The results suggest that the positive charge at the nitrogen of the tetrahydroisoquinoline portion, steric substitution at thenitrogen, planarity of the molecule or substitutions at C‐2, −3, −9, and −10 affect the AChE inhibitory activity of protoberberine alkaloids. Expand
HIV‐1 integrase inhibitory substances from Coleus parvifolius
For the purpose of discovering anti‐HIV‐1 agents from natural sources, water and EtOH extracts of 50 Thai plants were screened for their inhibitory activity against HIV‐1 integrase (IN), an enzymeExpand
Antibacterial, anti-inflammatory and anti-allergic activities of standardised pomegranate rind extract
TLDR
The potential use of standardised pomegranate rind extract as a nutraceutical for antibacterial, anti-inflammatory and anti-allergic proposes is supported. Expand
Antioxidant and cytotoxic activities of Thai medicinal plants named Khaminkhruea: Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria
TLDR
The stems of Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria, collectively known in southern Thailand as Khaminkhruea, were sequentially extracted with petroleum ether, chloroform, methanol, and boiling water to afford 12 crude extracts and compounds were determined by spectroscopic methods particularly NMR and mass spectrometry. Expand
Antitubercular sesterterpenes from the Thai sponge Brachiaster sp.
TLDR
The antitubercular and cytotoxic activities of all eight compounds were evaluated to reveal the potent activity of compounds 1, 2, 5, and 8, and among these, compound 2 showed an interesting bioactivity profile, in possessing potent antitubcular activity and being practically inactive in the cytotoxicity bioassay. Expand
Anti-cancer activity of compounds from Bauhinia strychnifolia stem.
TLDR
This is the first report of compounds 2 and 3 on anti-cancer activity and based on the anti- cancer activity of extracts and pure compounds isolated from Bauhinia strychnifolia stem, it might be suggested that this plant could be useful for treatment of cancer. Expand
Acetylcholinesterase-inhibiting steroidal alkaloid from the sponge Corticium sp.
TLDR
4-acetoxy-plakinamine B is the first steroidal alkaloid bearing a stigmastane skeleton ever been reported to exhibit such good potency in the acetylcholinesterase inhibition bioassay. Expand
Three types of cytotoxic natural caged-scaffolds: pure enantiomers or partial racemates.
TLDR
A 1:1 mixture of 1 and 3 showed potent in vitro cytotoxicity against an MCF-7 human breast cancer cell line with an IC50 value of 0.11 μg/mL and was determined by analysis of single-crystal X-ray diffraction and ECD spectroscopic data. Expand
Alginate beads for colon specific delivery of self-emulsifying curcumin
Abstract The aim of this study was to develop calcium alginate beads containing self-emulsifying curcumin (SE-Cur) for colon targeting. All formulations were prepared by ionotropic gelation andExpand
Kabiramides J and K, trisoxazole macrolides from the sponge Pachastrissa nux.
TLDR
Three trisoxazole macrolides possessing a 30-α,β-enone moiety were isolated from the sponge Pachastrissa nux, along with the previously reported kabiramides B, C, and D. Expand
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