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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
TLDR
The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions. Expand
Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
TLDR
Binformatics analysis on a virus genome from a patient with 2019-nCoV infection and compared it with other related coronavirus genomes provide the basis for starting further studies on the pathogenesis, and optimizing the design of diagnostic, antiviral and vaccination strategies for this emerging infection. Expand
Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility
TLDR
Besides satisfying the Koch’s postulates, this readily available hamster model is an important tool for studying transmission, pathogenesis, treatment, and vaccination against SARS-CoV-2. Expand
Zoonotic origins of human coronaviruses
TLDR
An overview of the existing knowledge about the seven HCoVs is presented, with a focus on the history of their discovery as well as their zoonotic origins and interspecies transmission, and the current CoV disease 2019 (COVID-19) epidemic is discussed. Expand
COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing
  • K. To, I. Hung, +17 authors K. Yuen
  • Medicine
  • Clinical infectious diseases : an official…
  • 25 August 2020
TLDR
The results suggest SARS-CoV-2 may continue to circulate among the human populations despite herd immunity due to natural infection or vaccination, and further studies of patients with re-infection will shed light on protective correlates important for vaccine design. Expand
Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19
  • H. Chu, J. Chan, +18 authors K. Yuen
  • Medicine
  • Clinical infectious diseases : an official…
  • 9 April 2020
TLDR
This study provided the first quantitative data on the comparative replication capacity and immune activation profile of SARS-CoV-2 and SARS -CoV infection in human lung tissues and provided important insights on the pathogenesis, high transmissibility, and asymptomatic infection of Sars-Cov-2. Expand
Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an
TLDR
This study presents the first quantitative data for tropism, replication kinetics, and cell damage of SARS-CoV-2, and provides novel insights into the lower incidence of diarrhoea, decreased disease severity, and reduced mortality in patients with COVID-19. Expand
Discovery of SARS-CoV-2 Antivirals through Large-scale Drug Repositioning
TLDR
A screen of the ReFRAME library of approximately 12,000 known drugs for antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) identified several candidate compounds with suitable activities and pharmacological profiles, which could potentially expedite the deployment of therapies for coronav virus disease 2019 (COVID-19). Expand
Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication
TLDR
It is demonstrated that host lipid metabolic remodeling was significantly associated with human-pathogenic coronavirus propagation and suggested that lipid metabolism regulation would be a common and druggable target for coronav virus infections. Expand
Attenuated Interferon and Proinflammatory Response in SARS-CoV-2–Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation
TLDR
Investigations suggested that this attenuated immune response to SARS-CoV-2 in moDCs was associated with viral antagonism of STAT1 phosphorylation, and these findings may explain the mild and insidious course of COVID-19 until late deterioration. Expand
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