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cGMP-elevating agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signaling pathway.
It is demonstrated that cGMP-elevating agents inhibit [3H]thymidine incorporation and thus the growth of VSMC, and this inhibition appears to attenuate EGF-activated signal transduction pathway by preventing Ras-dependent activation of Raf-1. Expand
Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor
It is concluded that cinnamophilin is a novel dual TX synthase inhibitor and TXA2 receptor antagonist and that it may be a useful tool for the investigation and treatment of diseases involving TXA 2 disorders. Expand
Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor.
It is concluded that butein, a novel cAMP-specific phosphodiesterase inhibitor, produced relaxation of rat aorta, an effect dependent on an intact endothelium and was markedly enhanced by cGMP-elevating agents. Expand
Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo.
PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-kappaB to promoter and exerts a beneficial effect in the mouse model of sepsis and protects mice against LPS-induced lethal toxicity. Expand
Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta
The results suggest that elevated levels of cyclic GMP may mediate the majority of the relaxation of the phenylephrine‐precontracted aorta induced by isoliquiritigenin, while the synergistic interaction with a low concentration of forskolin depends on an enhanced accumulation ofcyclic AMP. Expand
Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells.
The effect of catecholamine-induced VSMC proliferation is mediated via the activation of the chloroethylclonidine-sensitive alpha 1-adrenoceptors that triggers the phosphoinositide hydrolysis and activates the MAPK pathway, leading to DNA synthesis and cell proliferation. Expand
Cinnamophilin, a novel thromboxane A2 receptor antagonist, isolated from Cinnamomum philippinense.
- S. Yu, F. Ko, T. S. Wu, J. Lee, C. Teng
- Chemistry, Medicine
- European journal of pharmacology
- 11 April 1994
Results indicate that cinnamophilin is a selective thromboxane A2 receptor antagonist especially in rat aorta, and also possesses voltage-dependent Ca2+ channel blocking properties. Expand
CIS-19, a novel platelet activating factor receptor antagonist: in vitro and in vivo studies.
It is concluded that CIS-19 is an effective PAF receptor antagonist not only in vitro, but also in vivo. Expand
EDRF-release and Ca+(+)-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb Magnolia officinalis, in rat thoracic aorta.
It is concluded that magnolol relaxed vascular smooth muscle by releasing endothelium-derived relaxing factor (EDRF) and by inhibiting calcium influx through voltage-gated calcium channels. Expand
Effects of dicentrine on haemodynamic, plasma lipid, lipoprotein level and vascular reactivity in hyperlipidaemic rats
It is concluded that dicentrine decreases MAP, plasma CE, LDL‐CE, plasma TG, VLDL‐TG, vascular hyperreactivity to phenylephrine and increases HDL‐CE levels and may hold potential for the reduction of two of the major risk factors, hypertension and hyperlipidaemia, for cardiovascular disease. Expand