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Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties.
- M. Choudhary, S. Nawaz, +8 authors A. ur-Rahman
- Chemistry, MedicineBiochemical and biophysical research…
- 19 August 2005
The cholinesterase inhibitory potential along with calcium antagonistic ability and safe profile in human neutrophil viability assay could make compounds 1-5 possible drug candidates for further study to treat Alzheimer's disease and associated problems.
Biotransformation of an antimalarial drug, artemether by plant and fungal cell cultures
Abstract Biotransformation of 1 with Fusarium lini , Macrophomina phaseolina , and plant cell suspension culture of Azadirachta indica yielded five biotransformed products with the lacking of…
New antileishmanial sesquiterpene coumarins from Ferula narthex Boiss
Abstract Two new sesquiterpene coumarins, fnarthexone (1) and fnarthexol (2), along with three known coumarin derivatives, conferol (3), conferone (4) and umbelliferone (5), were isolated from the…
Analysis and development of structure-fragmentation relationships in withanolides using an electrospray ionization quadropole time-of-flight tandem mass spectrometry hybrid instrument.
- S. Musharraf, Arslan Ali, R. A. Ali, S. Yousuf, Atta-ur- Rahman, M. Choudhary
- Chemistry, MedicineRapid communications in mass spectrometry : RCM
- 15 January 2011
Structural elucidation and gas-phase fragmentation of ten withanolides (steroidal lactones) were studied using a positive ion electrospray ionization quadropole time-of-flight mass spectrometry (ESI-QqTOF-MS/MS) hybrid instrument, determining the influence of the presence and positions of hydroxyl and epoxy groups on product ion formation and stability.
In vitro Biological Activities of Gold(I) and Gold(III) Bis(N‐Heterocyclic Carbene) Complexes
The aim of this research is to evaluate for the first time the in vitro leishmanicidal activity and inhibition of α-glucosidase and β-glucuronidase of new gold(I) and gold(III) complexes involving…
Withanolides: Chemistry and Antitumor Activity 114
Withanolides are a group of naturally occurring C28 steroidal lactones with ergostane-based skeleton. They are highly oxygenated natural products, and the oxidation at various sites of skeleton is…
Characterization and biological activities of two copper(II) complexes with dipropylenetriamine and diamine as ligands.
- M. Al-Noaimi, M. I. Choudhary, +5 authors I. Warad
- Chemistry, MedicineSpectrochimica acta. Part A, Molecular and…
- 5 June 2014
The antiproliferative assay shows a high potential of these complexes to target Human keratinocyte cell line with IC50 values of 155 and 152μM, and the absorption spectrum of 2 in water was modeled by time-dependent density functional theory (TD-DFT).
Cholinesterase Inhibiting Withanolides from Withania somnifera.
Phytochemistry and antiglycation activity of Aloe sinkatana Reynolds
A new anthraquinone along with 10 known compounds were isolated from the leaves of Aloe sinkatana Reynolds (Aloaceae), and their structures were elucidated as the new compound…
Canarene: a triterpenoid with a unique carbon skeleton from Canarium schweinfurthii.
Canarene (1), a triterpene with an unprecedented carbon backbone, was isolated from Canarium schweinfurthii and showed weak α-glucosidase inhibitory activity, and its structure was unambiguously deduced by single-crystal X-ray diffraction.