S. Youssef

Publications82
h-index32
Citations6,312
Highly Influential Citations315
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The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
TLDR
It is shown that oral atorvastatin prevented or reversed chronic and relapsing paralysis and has pleiotropic immunomodulatory effects involving both APC and T-cell compartments.
Type II monocytes modulate T cell–mediated central nervous system autoimmune disease
TLDR
Adoptive transfer of type II monocytes reversed EAE, suppressed TH17 cell development and promoted both TH2 differentiation and expansion of Treg cells in recipient mice, identifying a central role for these cells in T cell immune modulation of autoimmunity.
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma.
Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells
TLDR
Osteopontin triggered recurrent relapses, promoted worsening paralysis and induced neurological deficits, including optic neuritis in models of multiple sclerosis including relapsing, progressive and multifocal experimental autoimmune encephalomyelitis.
1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A
TLDR
In vivo treatment of mice with ongoing experimental autoimmune encephalomyelitis diminishes paralysis and progression of the disease and reduces IL-17A-secreting T cells in the periphery and central nervous system (CNS).
Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite
TLDR
Catabolites of Trp suppressed proliferation of myelin-specific T cells and inhibited production of proinflammatory T helper–1 (TH1) cytokines, and offer a new strategy for treating TH1-mediated autoimmune diseases such as MS.
Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity
TLDR
It is observed that RAAS is up-regulated in brain lesions of MS and its animal model, experimental autoimmune encephalomyelitis, and modulation of the RAAS with inexpensive, safe pharmaceuticals used by millions worldwide is an attractive therapeutic strategy for application to human autoimmune diseases.
Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
TLDR
Unexpectedly, cystamine treatment increased transcription of one of the two genes shown to be neuroprotective for polyglutamine toxicity in Drosophila, dnaj, which provides a new treatment strategy for HD and other polyglUTamine diseases.
Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation
TLDR
It is reported that chronic inflammation resulting from severe dermatitis or autoimmune encephalitis leads to robust fusion of BMDCs with Purkinje neurons and formation of hundreds of binucleate heterokaryons per cerebellum, a 10–100-fold higher frequency than previously reported.
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin
TLDR
By connecting isoprenoid availability to regulation of Th1/Th2 fate, AT has elucidated a mechanism by which AT may suppress Th1-mediated central nervous system autoimmune disease.
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