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A 3 year minimum follow up of Endoprosthetic replacement for distal femoral fractures - An alternative treatment option.
INTRODUCTION Although the use of an endoprosthesis for distal femoral fractures remains a valid treatment option the widespread use is in its infancy. METHODOLOGY In this retrospective case series,Expand
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Environment-sensitive polymers for ophthalmic drug delivery
Ophthalmic drug delivery is a challenging endeavor for pharmaceutical scientists, owing to many physiological barriers of the eye. Ocular drugs are often formulated as solutions, but the precornealExpand
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Immediate Transoral Allogeneic Bone Grafting for Large Mandibular Defects. Less Morbidity, More Bone. A Paradigm in Benign Tumor Mandibular Reconstruction?
PURPOSE Reconstruction of hard tissue continuity defects caused by ablative tumor surgery has been traditionally reconstructed with autogenous bone grafts or microvascular free flaps. AlthoughExpand
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HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING.
The incidence of human papillomavirus (HPV)+ head and neck squamous cell carcinoma (HNSCC) has surpassed that of cervical cancer and is projected to increase rapidly until 2060. The co-evolution ofExpand
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Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition
BackgroundImmune checkpoint inhibitors (ICIs) for solid tumors, including those targeting programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), have shownExpand
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Land, Rights, Laws: Issues of Native Title
The Canadian decision of Tsilhqot’in Nation v British Columbia (BC Supreme Court, 2007) was a significant step in the resolution of a long-running timber dispute in western Canada, and the mostExpand
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Drug-Mimicking Nanofibrous Peptide Hydrogel for Inhibition of Inducible Nitric Oxide Synthase.
In this work, we develop a drug-mimicking nanofibrous peptide hydrogel that shows long-term bioactivity comparable to a small-molecule inhibitor of inducible nitric oxide synthase (iNOS). The iNOSExpand
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Microfracture is a stem cell stimulation technique to promote the healing of full thickness articulate cartilage defects Sixty-six patients have undergone microfracture for full thickness articulateExpand
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Biomaterial-Facilitated Immunotherapy for Established Oral Cancers.
We evaluated a peptide-based immunotherapy termed SynerGel: an injectable, biomaterial-based platform for intratumoral drug delivery. A drug-mimicking peptide hydrogel named L-NIL-MDP was loaded withExpand