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Acute aquaresis by the nonpeptide arginine vasopressin (AVP) antagonist OPC-31260 improves hyponatremia in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
TLDR
Results indicate that OPC-31260 is an effective therapeutic agent for hyponatremia in patients with SIADH.
Mechanism of diuretic action of U-62,066E, a κ opioid receptor agonist
Abstract The mechanism of the diuretic action of U-62,066E, a highly selective κ opioid agonist, was examined in unanesthetized rats and in isolated perfused inner medullary collecting ducts (IMCD).
The effect of osmotic pressure and angiotensin II on arginine vasopressin release from guinea pig hypothalamo-neurohypophyseal complex in organ culture.
TLDR
An organ culture system of the male guinea pig hypothalamo-neurohypophyseal complex is developed and the effect of various osmotic agents and angiotensin II on arginine vasopressin (AVP) release in vitro is investigated.
Mechanism of diuretic action of U-62,066E, a kappa opioid receptor agonist.
TLDR
The inhibition of the release of AVP is the major if not the entire mechanism of the diuretic action of U-62,066E in rats, and the effect of this drug on the water permeability of IMCD is ruled out.
METHOD FOR THE ASSAY OF ANTIDIURETIC HORMONE IN PLASMA WITH A NOTE ON THE ANTIDIURETIC TITER OF HUMAN PLASMA.
TLDR
The original procedure involves the trichloroacetic acid extraction of ADH from plasma, ether wash, and purification of the extract with XE-64 resin column chromatography followed by the ADH assay in water-loaded, ethanol-anesthetized rats with changes in conductivity of the urine as the index of response.
The effect of prostaglandins on the release of arginine vasopressin from the guinea pig hypothalamo-neurohypophyseal complex in organ culture.
TLDR
It is suggested that PGE2 and PGF2 alpha increase AVP release from the explants of HNC in organ culture, although PGF 2 alpha has a relatively weaker effect than P GE2, and PGs may modulate the regulation of AVPrelease in response to angiotensin II and osmotic stimulation.
Release of antidiuretic hormone from neurohypophysis in response to hemorrhage and infusion of hypertonic saline in dogs.
TLDR
A significant increase in plasma ADH titers was seen in intact dogs and dogs with diencephalic islands after infusion of hypertonic saline and in response to hemorrhage, which showed a massive increase in ADH levels in plasma.
Effect of administration of corticotropin-releasing hormone and glucocorticoid on arginine vasopressin response to osmotic stimulus in normal subjects and patients with hypocorticotropinism without
TLDR
It is suggested that patients with hypocorticotropinism have partial diabetes insipidus, in which impairment of central CRH action might be, at least in part, involved in the augmentation of AVP release.
Synergistic interactions between footshocks and non-osmotic hypovolemia on vasopressin secretion in rats
TLDR
It is demonstrated that non-osmotic hypovolemia but not body fluid hyperosmolarity interact significantly and synergistically with footshocks to potentiate vasopressin secretion.
Inhibition of elevated arginine vasopressin secretion in response to osmotic stimulation and acute haemorrhage by U‐62066E, a κ‐opioid receptor agonist
TLDR
It is suggested that the κ‐opioid receptor activation reduces the increase in AVP secretion evoked by these two different stimuli and that the inhibitory involvement occurs in the neural lobe in the process of A VP secretion.
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