Activity-Dependent Proteolytic Cleavage of Neuroligin-1
- Kunimichi Suzuki, Y. Hayashi, T. Iwatsubo
- BiologyNeuron
- 18 October 2012
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate
- T. Tomita, N. Takasugi, T. Iwatsubo
- Biology, ChemistryAlzheimer's & Dementia
- 4 May 2011
It is shown that the activity of β-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for amyloid-β peptide production, is modulated by S1P in mouse neurons, suggesting that cellular S1p directly modulates BACE1 activity.
Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator
- Koji Takeo, S. Tanimura, T. Iwatsubo
- Chemistry, BiologyProceedings of the National Academy of Sciences
- 9 July 2014
A model for the mechanism of action of the phenylimidazole-type GSM in which binding at the luminal side of PS induces a conformational change in the catalytic center of γ-secretase to modulate Aβ production is provided.
BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
- T. Miyagawa, Ihori Ebinuma, T. Tomita
- Biology, ChemistryHuman Molecular Genetics
- 14 May 2016
It is reported that the depletion of BIN1 increases cellular BACE1 levels through impaired endosomal trafficking and reduces Bace1 lysosomal degradation, resulting in increased Aβ production.
Phenylpiperidine‐type γ‐secretase modulators target the transmembrane domain 1 of presenilin 1
- Y. Ohki, Takuya Higo, T. Iwatsubo
- Biology, ChemistryEMBO Journal
- 30 November 2011
It is shown that a phenylpiperidine‐type compound GSM‐1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1) by photoaffinity labelling experiments combined with limited digestion, indicating an allosteric action of G SM‐1 by directly binding to the TMD1 of PS1, pinpointing the target structure of the phenylmethine‐type GSMs.
Identification of novel deoxyribofuranosyl indole antimicrobial agents
- A. Paudel, H. Hamamoto, Yoshihisa Kobayashi, S. Yokoshima, T. Fukuyama, K. Sekimizu
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 14 December 2011
Three novel deoxyribofuranosyl indole derivatives, FG050227 (1), FG050223 (2) and FG050204 (3), were identified as antimicrobial agents effective against Gram-positive bacterial strains and some…
High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway
Using high-throughput screening, a potent small molecule was found that suppressed the S. mutans quorum-sensing pathway through inhibition of PEP activity and showed that PEP is a good target for inhibitors of the Streptococcus quorum -sensing system.
An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves
- Kenward Vong, S. Eda, Katsunori Tanaka
- ChemistryNature Communications
- 1 December 2019
An artificial metalloenzyme-based ethylene probe can be used to detect ethylene in plants with improved spatiotemporal resolution and represents an example of an ArM biosensor, designed specifically for the spatial and temporal detection of a biological metabolite previously not accessible using enzyme biosensors.
Total synthesis of (-)-lepenine.
- Y. Nishiyama, Y. Han-ya, S. Yokoshima, T. Fukuyama
- ChemistryJournal of the American Chemical Society
- 24 April 2014
The first asymmetric total synthesis of lepenine has been accomplished, resulting in stereoselective construction of the unique hexacyclic system.
Total synthesis of lysergic acid.
- S. Umezaki, S. Yokoshima, T. Fukuyama
- ChemistryOrganic Letters
- 6 August 2013
A total synthesis of lysergic acid was accomplished using stereoselective construction of the stereogenic centers at the allylic positions by using the Evans aldol reaction and a sequential process with a ring-closing metathesis and an intramolecular Heck reaction to construct the C and D rings.
...
...