Spine-shaped gold protrusions improve the adherence and electrical coupling of neurons with the surface of micro-electronic devices
- Aviad Hai, A. Dormann, M. Spira
- BiologyJournal of the Royal Society Interface
- 6 December 2009
It is found that neurons cultured on a gold-spine matrix, functionalized by a cysteine-terminated peptide with a number of RGD repeats, readily engulf the spines, forming tight apposition, and the recorded field potentials of cultured Aplysia neurons are significantly larger using gold- Spine electrodes in comparison with flat electrodes.
Improved Neuronal Adhesion to the Surface of Electronic Device by Engulfment of Protruding Micro-Nails Fabricated on the Chip Surface
- M. Spira, D. Kamber, J. Shappir
- BiologyTRANSDUCERS - International Solid-State Sensors…
- 10 June 2007
To increase the clefts electrical resistance the authors fabricated gold micronails that protrude from the transistor gate surface that functionalized by phagocytosis facilitating peptides forming tight physical contact between the cells and the surface of the device.
Impaired Replication Stress Response in Cells from Immunodeficiency Patients Carrying Cernunnos/XLF Mutations
- M. Schwartz, Y. Oren, B. Kerem
- BiologyPLoS ONE
- 18 February 2009
This is the first study of a NHEJ syndrome showing association with impaired cellular response to replication stress conditions and this results provide evidence for the role of Cernunnos/XLF in repair of DSBs and maintenance of genomic stability under replication Stress conditions.
Polyaniline-coated single-walled carbon nanotubes: synthesis, characterization and impact on primary immune cells
- S. Ben-Valid, H. Dumortier, S. Yitzchaik
- Biology
- 9 March 2010
A novel synthetic route for the formation of single-walled carbon nanotube (SWCNT)–polyaniline (PANI) hybrids by in situ chemical polymerization is reported, which preserves the surfactant and is characterized by a tight binding between SWCNTs and PANI.
Oxytocin-Monolayer-Based Impedimetric Biosensor for Zinc and Copper Ions
- K. Tadi, I. Alshanski, S. Yitzchaik
- BiologyACS Omega
- 8 December 2017
The OT sensor was able to distinguish between healthy control and multiple sclerosis patients diluted sera samples by determining the Zn/Cu ratio similar to the state-of-the-art techniques and was ultrasensitive to Zn2+ and Cu2+ ions at physiological pH and not to other biologically relevant ions.
Searching for photochromic liquid crystals Spironaphthoxazine substituted with a mesogenic group
- L. Shragina, F. Buchholtz, S. Yitzchaik, V. Krongauz
- Chemistry
- 1 May 1990
Abstract A number of photochromic spiropyrans and spirooxazines containing mesogenic groups were synthesized. Only one of them, spiro-indoline-naphthoxazine with mesogenic substituent,…
Monitoring selectivity in kinase-promoted phosphorylation of densely packed peptide monolayers using label-free electrochemical detection.
- Elza Snir, J. Joore, P. Timmerman, S. Yitzchaik
- Chemistry, BiologyLangmuir
- 29 July 2011
This paper describes remarkably high sensitivities in the label-free detection of kinase-promoted phosphorylation for 14 different peptide substrates on electrode-immobilized monolayers (gold or…
1,4;5,8-naphthalene-tetracarboxylic diimide derivatives as model compounds for molecular layer epitaxy
- Y. Ofir, A. Zelichenok, S. Yitzchaik
- Materials Science, Chemistry
- 31 May 2006
The physical properties and finite size effects observed in 1,4;5,8-naphthalene-tetracarboxylicdiimide (NTCDI)-based organic multilayers assembled by molecular layer epitaxy (MLE) are investigated by…
Experimental and theoretical analysis of neuron-transistor hybrid electrical coupling: the relationships between the electro-anatomy of cultured Aplysia neurons and the recorded field potentials.
- A. Cohen, J. Shappir, S. Yitzchaik, M. Spira
- BiologyBiosensors & bioelectronics
- 15 December 2006
Glutamate sensing with enzyme-modified floating-gate field effect transistors.
- D. Braeken, D. Rand, C. Bartic
- BiologyBiosensors & bioelectronics
- 15 April 2009
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