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Molecular Identification of a Malaria Merozoite Surface Sheddase
Proteolytic shedding of surface proteins during invasion by apicomplexan parasites is a widespread phenomenon, thought to represent a mechanism by which the parasites disengage adhesin-receptorExpand
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A multifunctional serine protease primes the malaria parasite for red blood cell invasion
The malaria parasite Plasmodium falciparum replicates within an intraerythrocytic parasitophorous vacuole (PV). Rupture of the host cell allows release (egress) of daughter merozoites, which invadeExpand
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On the molecular mechanisms of mitotic kinase activation
During mitosis, human cells exhibit a peak of protein phosphorylation that alters the behaviour of a significant proportion of proteins, driving a dramatic transformation in the cell's shape,Expand
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A Kinetic Test Characterizes Kinase Intramolecular and Intermolecular Autophosphorylation Mechanisms
Mathematical analysis of enzyme kinetics reveals different modes of kinase autophosphorylation. Autoactivation Mechanisms Kinases are regulated in multiple ways, including through phosphorylation ofExpand
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Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization
Mitotic spindle assembly requires the regulated activities of protein kinases such as Nek7 and Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated by the Nek9Expand
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Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity.
We report herein a series of Nek2 inhibitors based on an aminopyridine scaffold. These compounds have been designed by combining key elements of two previously discovered chemical series. StructureExpand
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The structural mechanisms that underpin mitotic kinase activation.
In eukaryotic cells, the peak of protein phosphorylation occurs during mitosis, switching the activities of a significant proportion of proteins and orchestrating a wholesale reorganization of cellExpand
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The Ys and wherefores of protein kinase autoinhibition.
Protein phosphorylation is a key reaction in the regulation of cellular events and is catalysed by over 500 protein kinases in humans. The activities of protein kinases are strictly controlledExpand
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Image based fingerprint verification
TLDR
This paper investigates fingerprint-scanned image verification via an inverse fast Fourier transform after a thinning process. Expand
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Design of potent and selective hybrid inhibitors of the mitotic kinase Nek 2 : SAR , structural biology and cellular activity †
We report herein a series of Nek2 inhibitors based on an aminopyridine scaffold. These compounds have been designed by combining key elements of two previously discovered chemical series. StructureExpand
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