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Subcellular Discharge of a Serine Protease Mediates Release of Invasive Malaria Parasites from Host Erythrocytes
The most virulent form of malaria is caused by waves of replication of blood stages of the protozoan pathogen Plasmodium falciparum. The parasite divides within an intraerythrocytic parasitophorousExpand
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Determining the differences in actin binding by human ADF and cofilin.
The actin-depolymerizing factor (ADF)/cofilin family of proteins play an essential role in actin dynamics and cytoskeletal re-organization. Human tissues express two isoforms in the same cells, ADFExpand
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Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum.
Newly replicated Plasmodium falciparum parasites escape from host erythrocytes through a tightly regulated process that is mediated by multiple classes of proteolytic enzymes. However, theExpand
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Uncoupling actin filament fragmentation by cofilin from increased subunit turnover.
The actin depolymerizing factor (ADF)/cofilin family of proteins interact with actin monomers and filaments in a pH-sensitive manner. When ADF/cofilin binds F-actin it induces a change in the helicalExpand
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Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle
The malaria parasite Plasmodium falciparum replicates in an intraerythrocytic parasitophorous vacuole (PV). The most abundant P. falciparum PV protein, called SERA5, is essential in blood stages andExpand
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Interaction of ADP‐ribosylated actin with actin binding proteins
Actin ADP‐ribosylated at Arg177 was previously shown not to polymerise after increasing the ionic strength, but to cap the barbed ends of filaments. Here we confirm that the polymerisation ofExpand
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EML4-ALK Variants: Biological and Molecular Properties, and the Implications for Patients
Since the discovery of the fusion between EML4 (echinoderm microtubule associated protein-like 4) and ALK (anaplastic lymphoma kinase), EML4-ALK, in lung adenocarcinomas in 2007, and the subsequentExpand
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Molecular Determinants for Subcellular Trafficking of the Malarial Sheddase PfSUB2
The malaria merozoite invades erythrocytes in the vertebrate host. Iterative rounds of asexual intraerythrocytic replication result in disease. Proteases play pivotal roles in erythrocyte invasion,Expand
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Action at the Y-branch
Cell motility depends on reorganization of the actin filament network just beneath the plasma membrane. In a Perspective, [Weeds and Yeoh][1] discuss the high-resolution structure of the Arp2/3Expand
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Structure. Action at the Y-branch.
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