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IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF‐1 degradation by miR‐195
Results identify IGF2BP2 as a post‐transcriptional regulatory mRNA‐binding factor that contributes to CRC carcinogenesis and regulates RAF1 expression through blocking its degradation by miR‐195.
Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma
The underlying mechanism of HBV DNA integration in liver diseases was determined and laid the foundation for future studies on the pathogenesis of liver cancer.
Pancreaticoduodenectomy with portal vein/superior mesenteric vein resection for patients with pancreatic cancer with venous invasion.
Efficacy of transcatheter arterial chemoembolization for liver metastases arising from pancreatic cancer
TACE is an effective therapy for treating liver metastases from pancreatic malignancy and Pathological type and extrahepatic metastasis of pancreatic tumor are independent risk factors for patients' prognosis.
Circulating Tumor DNA as a Potential Marker to Detect Minimal Residual Disease and Predict Recurrence in Pancreatic Cancer
Postoperative ctDNA detection provides strong evidence of MRD and identifies patients with a high risk of relapse and is a promising approach for personalized patient management during postoperative follow-up.
Meta-Analysis of Laparoscopic versus Open Hepatectomy for Live Liver Donors
LLDH appears to be a safe and effective option for LDLT and improves donors’ perioperative outcomes as compared with OLDH, with no significant difference in other outcomes.
A rare variation of celiac trunk and hepatic artery complicating pancreaticoduodenectomy
The patient was diagnosed with cholangiocarcinoma and accompanying extremely rare variation of celiac trunk and hepatic artery and had an uneventful postoperative evolution.
HBV Integration-mediated Cell Apoptosis in HepG2.2.15
The results suggest that HBV integration of DPP7 was involved in cell apoptosis, which resulted in increased apoptosis through upregulation of the Bax/Bcl2 ratio in HepG2 cells.
Bioinformatics Method to Predict Two Regulation Mechanism: TF–miRNA–mRNA and lncRNA–miRNA–mRNA in Pancreatic Cancer
- S. Ye, Liu Yang, Xinyi Zhao, Wei Song, Weilin Wang, Shusen Zheng
- BiologyCell Biochemistry and Biophysics
- 3 August 2014
In this study, integration of published multi-level expression data and bioinformatics computational approach was used to predict two regulation mechanisms: transcription factors (TF)–miRNA–mRNA regulation and long non-coding RNA(lncRNA)–MiRNAs–m RNA regulation.
TP53 and RET may serve as biomarkers of prognostic evaluation and targeted therapy in hepatocellular carcinoma
Patients with TP53 mutations, RET mutations and sorafenib-targeted gene mutations were demonstrated to be associated with poor HCC prognosis, which suggests that both TP53 and RET may serve as biomarkers of prognostic evaluation and targeted therapy in HCC.