• Publications
  • Influence
Pharmacophore modeling and applications in drug discovery: challenges and recent advances.
  • S. Yang
  • Biology, Medicine
  • Drug discovery today
  • 1 June 2010
Pharmacophore approaches have become one of the major tools in drug discovery after the past century's development. Various ligand-based and structure-based methods have been developed for improvedExpand
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Therapeutic target database update 2014: a resource for targeted therapeutics
Here we describe an update of the Therapeutic Target Database (http://bidd.nus.edu.sg/group/ttd/ttd.asp) for better serving the bench-to-clinic communities and for enabling more convenient dataExpand
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Cationic nanocarriers induce cell necrosis through impairment of Na+/K+-ATPase and cause subsequent inflammatory response
Nanocarriers with positive surface charges are known for their toxicity which has limited their clinical applications. The mechanism underlying their toxicity, such as the induction of inflammatoryExpand
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ID-Score: A New Empirical Scoring Function Based on a Comprehensive Set of Descriptors Related to Protein-Ligand Interactions
Scoring functions have been widely used to assess protein-ligand binding affinity in structure-based drug discovery. However, currently commonly used scoring functions face some challenges includingExpand
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Chloroquine Inhibits Colon Cancer Cell Growth In Vitro and Tumor Growth In Vivo via Induction of Apoptosis
The present study was to investigate the anticancer effect of chloroquine on proliferation of mouse colon cancer cell line CT26 in vivo and in vitro and the possible mechanism. We found thatExpand
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Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer.
Metastatic breast cancers are hard to treat and almost always fatal. Chloroquine diphosphate, a derivative of quinine, has long been used as a potent and commonly used medicine against differentExpand
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MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice.
  • Z. Wu, P. Jiao, +8 authors H. Xu
  • Biology, Medicine
  • The Journal of clinical investigation
  • 1 November 2010
Insulin resistance results in dysregulated hepatic gluconeogenesis that contributes to obesity-related hyperglycemia and progression of type 2 diabetes mellitus (T2DM). Recent studies show that MAPKExpand
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Dopamine‐loaded blood exosomes targeted to brain for better treatment of Parkinson's disease
  • Mengke Qu, Q. Lin, +8 authors Xun Sun
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 10 October 2018
Abstract Parkinson's disease (PD), one of the most common movement and neurodegenerative disorders, is challenging to treat, largely because the blood‐brain barrier blocks passage of most drugs. HereExpand
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Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine.
  • Y. Li, R. Zhu, +17 authors X. Cen
  • Medicine, Biology
  • The Journal of neuroscience : the official…
  • 16 September 2015
UNLABELLED Recent evidence suggests that histone modifications play a role in the behavioral effects of cocaine in rodent models. Histone arginine is known to be methylated by protein arginineExpand
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Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator in the process of insulin signaling and a promising drug target for diabetes and obesity. Derivatives of oleanolic acid wereExpand
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