• Publications
  • Influence
Critical Role of Proinflammatory Cytokine IL‐6 in Allograft Rejection and Tolerance
The proinflammatory cytokine IL‐6 plays an important role in controlling T‐cell differentiation, especially the development of Th17 and regulatory T cells. To determine the function of IL‐6 inExpand
  • 68
  • 5
The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes
Type 1 diabetes (T1D) remains a major health problem worldwide, with a steadily rising incidence yet no cure. Phosphoinositide 3-kinase-γ (PI3Kγ), a member of a family of lipid kinases expressedExpand
  • 26
  • 2
  • PDF
Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes
OBJECTIVE A number of clinical trials are underway to test whether mesenchymal stem cells (MSCs) are effective in treating various diseases, including type 1 diabetes. Although this cell therapyExpand
  • 111
  • 1
  • PDF
Polylactide‐cyclosporin A nanoparticles for targeted immunosuppression
  • J. Azzi, L. Tang, +10 authors R. Abdi
  • Chemistry, Medicine
  • FASEB journal : official publication of the…
  • 1 October 2010
Polymeric nanoparticles (NPs), prepared via coprecipitation of drugs and polymers, are promising drug delivery vehicles for treating diseases with improved efficacy and reduced toxicity. Here, weExpand
  • 65
  • 1
  • PDF
Intact B7‐H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses
Ligands of the B7 family provide both positive and negative costimulatory signals to the CD28 family of receptors on T lymphocytes, the balance of which determines the immune response. B7‐H3 is aExpand
  • 24
  • 1
Mesenchymal stem cells express serine protease inhibitor to evade the host immune response.
Clinical trials using mesenchymal stem cells (MSCs) have been initiated worldwide. An improved understanding of the mechanisms by which allogeneic MSCs evade host immune responses is paramount toExpand
  • 41
In Vivo Function of Immune Inhibitory Molecule B7‐H4 in Alloimmune Responses
B7 ligands deliver both costimulatory and coinhibitory signals to the CD28 family of receptors on T lymphocytes, the balance between which determines the ultimate immune response. Although B7‐H4, aExpand
  • 16
Donor Antioxidant Strategy Prolongs Cardiac Allograft Survival by Attenuating Tissue Dendritic Cell Immunogenicity†
Ischemic reperfusion injury (IRI) enhances allograft immunogenicity, worsens transplantation outcome, and is the primary cause of activation of the recipient innate immune response, resulting inExpand
  • 18