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Ghrelin Is Expressed in a Novel Endocrine Cell Type in Developing Rat Islets and Inhibits Insulin Secretion from INS-1 (832/13) Cells
Ghrelin is produced mainly by endocrine cells in the stomach and is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). It also influences feeding behavior, metabolicExpand
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The interplay between DNA repair and autophagy in cancer therapy
DNA is the prime target of anticancer treatments. DNA damage triggers a series of signaling cascades promoting cellular survival, including DNA repair, cell cycle arrest, and autophagy. The elevatedExpand
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Autophagy attenuates noise-induced hearing loss by reducing oxidative stress.
AIMS Reactive oxygen species play a dual role in mediating both cell stress and defense pathways. Here, we used pharmacological manipulations and siRNA silencing to investigate the relationshipExpand
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Regeneration of Stereocilia of Hair Cells by Forced Atoh1 Expression in the Adult Mammalian Cochlea
The hallmark of mechanosensory hair cells is the stereocilia, where mechanical stimuli are converted into electrical signals. These delicate stereocilia are susceptible to acoustic trauma andExpand
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A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis
Objective Helper T (Th) cell responses are critical for the pathogenesis of Helicobacter pylori-induced gastritis. Th22 cells represent a newly discovered Th cell subset, but their relevance to H.Expand
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Mutation and methylation of hMLH1 in gastric carcinomas with microsatellite instability.
AIM To appraise the correlation of mutation and methylation of hMSH1 with microsatellite instability (MSI) in gastric cancers. METHODS Mutation of hMLH1 was detected by Two-dimensionalExpand
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Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats
Background In mammals, hair cells do not undergo spontaneous regeneration when they are damaged and result in permanent hearing loss. Previous studies in cultured Organ of Corti dissected fromExpand
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microRNA-27b suppresses mouse MSC migration to the liver by targeting SDF-1αin vitro.
The SDF-1/CXCR4 axis is critical for inducing stem cell mobilization into the circulation, for homing stem cells to the site of injury, and for stem cell participation in the regeneration of liverExpand
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Effect of Helicobacter pylori infection on expression of Bcl-2 family members in gastric adenocarcinoma.
AIM To investigate the effect of Helicobacter pylori (H pylori) infection on the expressions of Bcl-2 family members in gastric adenocarcinoma. METHODS Gastric adenocarcinoma and resection marginExpand
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microRNA detection in feces, sputum, pleural effusion and urine: novel tools for cancer screening (Review).
microRNAs (miRNAs) are short non-coding RNA sequences that play important roles in the regulation of gene expression. They have significant regulatory functions in basic cellular processes, includingExpand
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