• Publications
  • Influence
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
PTEN is a tumor suppressor gene mutated in many human cancers. We generated a bronchioalveolar epithelium-specific null mutation of Pten in mice [SP-C-rtTA/(tetO)(7)-Cre/Pten(flox/flox)Expand
  • 156
  • 8
Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity.
RATIONALE Injury to alveolar epithelial cells (AECs) and to their repair process is integral to the pathogenesis of acute lung injury (ALI) and idiopathic pulmonary fibrosis (IPF). The mechanismsExpand
  • 62
  • 6
Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation.
Acute lung injury is a critical illness syndrome consisting of acute respiratory failure with bilateral pulmonary infiltrates that is refractory to current therapies. Acute lung injury isExpand
  • 47
  • 3
Breakdown of Epithelial Barrier Integrity and Overdrive Activation of Alveolar Epithelial Cells in the Pathogenesis of Acute Respiratory Distress Syndrome and Lung Fibrosis
Individual alveolar epithelial cells (AECs) collaboratively form a tight barrier between atmosphere and fluid-filled tissue to enable normal gas exchange. The tight junctions of AECs provideExpand
  • 30
  • 3
Syk expression and novel function in a wide variety of tissues.
Syk protein-tyrosine kinase has been implicated in a variety of hematopoietic cell responses, in particular immunoreceptor signaling events that mediate diverse cellular responses includingExpand
  • 147
  • 2
The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections
Pneumonia generates considerable negative impacts on the elderly. Despite the widespread uses of vaccines and appropriate antibiotics, the morbidity and mortality of elderly pneumonia areExpand
  • 16
  • 2
Accumulation of aluminum in cancers of the liver, stomach, duodenum and mammary glands of rats.
The aim of the present investigation was to evaluate abnormal changes in trace element concentrations during carcinogenesis. First, Al, Zn and Cu in the liver tissues of rats were measured by atomicExpand
  • 12
  • 2
Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice.
Mice deficient in the Syk tyrosine kinase showed severe petechiae in utero and died shortly after birth. The mechanism of this bleeding, however, remains unknown. Here it is shown that this bleedingExpand
  • 59
  • 1
Isolation of human β-defensin-4 in lung tissue and its increase in lower respiratory tract infection
BackgroundHuman β-defensin-4 (hBD-4), a new member of the β-defensin family, was discovered by an analysis of the genomic sequence. The objective of this study was to clarify hBD-4 expression inExpand
  • 39
  • 1
Ghrelin alleviates paclitaxel‐induced peripheral neuropathy by reducing oxidative stress and enhancing mitochondrial anti‐oxidant functions in mice
ABSTRACT Paclitaxel is an effective chemotherapeutic agent, but has some treatment‐limiting adverse effects that markedly decrease patients’ quality of life. Peripheral neuropathy is one of these,Expand
  • 14
  • 1