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Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
- S. Yanagi, H. Kishimoto, +12 authors A. Suzuki
- The Journal of clinical investigation
- 1 October 2007
PTEN is a tumor suppressor gene mutated in many human cancers. We generated a bronchioalveolar epithelium-specific null mutation of Pten in mice [SP-C-rtTA/(tetO)(7)-Cre/Pten(flox/flox)… Expand
Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity.
- Kahori Miyoshi, S. Yanagi, +9 authors M. Nakazato
- American journal of respiratory and critical care…
- 5 March 2013
RATIONALE Injury to alveolar epithelial cells (AECs) and to their repair process is integral to the pathogenesis of acute lung injury (ALI) and idiopathic pulmonary fibrosis (IPF). The mechanisms… Expand
Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation.
Acute lung injury is a critical illness syndrome consisting of acute respiratory failure with bilateral pulmonary infiltrates that is refractory to current therapies. Acute lung injury is… Expand
Breakdown of Epithelial Barrier Integrity and Overdrive Activation of Alveolar Epithelial Cells in the Pathogenesis of Acute Respiratory Distress Syndrome and Lung Fibrosis
- S. Yanagi, Hironobu Tsubouchi, A. Miura, N. Matsumoto, M. Nakazato
- BioMed research international
- 7 October 2015
Individual alveolar epithelial cells (AECs) collaboratively form a tight barrier between atmosphere and fluid-filled tissue to enable normal gas exchange. The tight junctions of AECs provide… Expand
Syk expression and novel function in a wide variety of tissues.
- S. Yanagi, R. Inatome, T. Takano, H. Yamamura
- Biology, Medicine
- Biochemical and biophysical research…
- 2 November 2001
Syk protein-tyrosine kinase has been implicated in a variety of hematopoietic cell responses, in particular immunoreceptor signaling events that mediate diverse cellular responses including… Expand
The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections
- S. Yanagi, Hironobu Tsubouchi, A. Miura, A. Matsuo, N. Matsumoto, M. Nakazato
- Medicine, Biology
- International journal of molecular sciences
- 25 February 2017
Pneumonia generates considerable negative impacts on the elderly. Despite the widespread uses of vaccines and appropriate antibiotics, the morbidity and mortality of elderly pneumonia are… Expand
Accumulation of aluminum in cancers of the liver, stomach, duodenum and mammary glands of rats.
- K. Ogoshi, S. Yanagi, T. Moriyama, H. Arachi
- Chemistry, Medicine
- Journal of trace elements and electrolytes in…
- 1 March 1994
The aim of the present investigation was to evaluate abnormal changes in trace element concentrations during carcinogenesis. First, Al, Zn and Cu in the liver tissues of rats were measured by atomic… Expand
Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice.
- S. Yanagi, R. Inatome, J. Ding, H. Kitaguchi, V. Tybulewicz, H. Yamamura
- Biology, Medicine
- 1 November 2001
Mice deficient in the Syk tyrosine kinase showed severe petechiae in utero and died shortly after birth. The mechanism of this bleeding, however, remains unknown. Here it is shown that this bleeding… Expand
Isolation of human β-defensin-4 in lung tissue and its increase in lower respiratory tract infection
BackgroundHuman β-defensin-4 (hBD-4), a new member of the β-defensin family, was discovered by an analysis of the genomic sequence. The objective of this study was to clarify hBD-4 expression in… Expand
Ghrelin alleviates paclitaxel‐induced peripheral neuropathy by reducing oxidative stress and enhancing mitochondrial anti‐oxidant functions in mice
- N. Ishii, Hironobu Tsubouchi, +4 authors M. Nakazato
- Chemistry, Medicine
- European journal of pharmacology
- 15 January 2018
ABSTRACT Paclitaxel is an effective chemotherapeutic agent, but has some treatment‐limiting adverse effects that markedly decrease patients’ quality of life. Peripheral neuropathy is one of these,… Expand