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- Publications
- Influence
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.
- A. Fukuhara, M. Matsuda, +19 authors I. Shimomura
- Medicine
- Science
- 1 August 2005
Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceral… Expand
Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty
- I. Shimomura, Tohru Funahasm, +9 authors Y. Matsuzawa
- Medicine
- Nature Medicine
- 1 July 1996
The presence of obesity increases the risk of thrombotic vascular diseases. The role of fat accumulation and its effect on plasminogen activator inhibitor–1 (PAI–1) levels was investigated in humans… Expand
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
- A. Fukuhara, M. Matsuda, +19 authors I. Shimomura
- Biology
- Science
- 21 January 2005
Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceral… Expand
Angiopoietin-Like Protein3 Regulates Plasma HDL Cholesterol Through Suppression of Endothelial Lipase
- M. Shimamura, M. Matsuda, +15 authors I. Shimomura
- Chemistry, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 16 November 2006
Objectives—A low level of high-density lipoprotein (HDL) in plasma has been recognized as an aspect of metabolic syndrome and as a crucial risk factor of cardiovascular events. However, the… Expand
Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation
- G. Watts, S. Gidding, +19 authors J. Kastelein
- Medicine
- European journal of preventive cardiology
- 1 July 2015
Familial hypercholesterolaemia (FH) is a dominantly inherited disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL) cholesterol and causes premature coronary heart… Expand
Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation.
- G. Watts, S. Gidding, +19 authors J. Kastelein
- Medicine
- International journal of cardiology
- 15 February 2014
Familial hypercholesterolaemia (FH) is a dominantly inherited disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL) cholesterol and causes premature coronary heart… Expand
Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation.
- G. Watts, S. Gidding, +19 authors J. Kastelein
- Medicine
- Journal of clinical lipidology
- 1 March 2014
Familial hypercholesterolemia (FH) is a dominantly inherited disorder present from birth that markedly elevates plasma low-density lipoprotein cholesterol and causes premature coronary heart disease.… Expand
Molecular mechanisms of cholesteryl ester transfer protein deficiency in Japanese.
- Makoto Nagano, S. Yamashita, +11 authors Y. Matsuzawa
- Medicine
- Journal of atherosclerosis and thrombosis
- 2004
Plasma cholesteryl ester transfer protein (CETP) facilitates the transfer of cholesteryl ester (CE) from high density lipoprotein (HDL) to apolipoprotein B-containing lipoproteins. Since CETP… Expand
HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins.
- Hanayuki Okura, S. Yamashita, +7 authors A. Matsuyama
- Chemistry, Medicine
- Journal of atherosclerosis and thrombosis
- 30 June 2010
AIM
HDL has anti-inflammatory effects on macrophages, although the mechanism of action remains unclear. We hypothesized that HDL suppresses the conversion of macrophage-secreted factors into… Expand
Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia…
- R. Santos, S. Gidding, +22 authors S. Yamashita
- Medicine
- The lancet. Diabetes & endocrinology
- 1 October 2016
Familial hypercholesterolaemia is common in individuals who had a myocardial infarction at a young age. As many as one in 200 people could have heterozygous familial hypercholesterolaemia, and up to… Expand