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Stereoselective Total Synthesis of (+/-)-Swainsonine Based on Endo Mode Cyclization.
A new stereoselective total synthesis of (+/-)-swainsonine is described. Successive treatment of cis-3,4-epoxy-7-(p-toluenesulfonamido)-1-heptyne with dicobalt octacarbonyl, Lewis acid, andExpand
Co2(CO)8-mediated endo mode cyclization of epoxy-alcohol: synthesis of 2-ethynyl-3-hydroxy-2-methyltetrahydropyran and 2-ethynyl-3-hydroxy-3-methyltetrahydropyran derivatives.
Successive treatment of 4,5-epoxy-5-methyl-7-trimethylsilyl-6-heptyne-1-ol with Co2(CO)8 at 0 degrees C and a catalytic amount of BF3 x OEt2 at -78 degrees C gave the tetrahydropyran derivatives withExpand
N-alkoxyalkyl derivatives -n, n-dialkylamine or salts thereof and agents for treating neurodegenerative diseases comprising the same.
Un derivado de N-alcoxialquil-N,N-dialquilamina representado por la siguiente formula general, o su sal: ** ver formula** en la que R 1 y R 2 son iguales o diferentes y representan al menos un grupoExpand
N-alkoxyalkyl-n,n-dialkylamine derivatives or salts thereof, and agents for treating neurodegenerative diseases comprising the same
N-Alkoxyalkyl-N,N-dialkylamine derivatives of general formula [1] or salts thereof, which exhibit antihypoxic, nerve protecting and nerve regeneration promoting effects and are useful as remedies forExpand