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MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
TLDR
The findings demonstrate the pivotal function of MT1-MMP in connective tissue metabolism, and illustrate that modeling of the soft connective tissues matrix by resident cells is essential for the development and maintenance of the hard tissues of the skeleton.
Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization
TLDR
A central role for the fibronectin receptor in regulating cell adhesion and migration is suggested, which is not required for fibroblast motility but instead retards migration and is critically involved in fibronctin retention and matrix assembly.
Electron microscopy and structural model of human fibronectin receptor.
TLDR
Computer‐assisted structure prediction using the published amino acid sequence of both subunits showed differences in the secondary structure of the tails, the alpha‐tail being rich in beta‐strands, the beta‐tail having five cysteine‐rich repeats analogous to the EGF‐like repeats of laminin.
Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly
TLDR
The results indicate that single subunit chimeric integrins can mimic and/or inhibit endogenous integrin receptor function, presumably by interacting with cytoplasmic components critical for endogenous Integrin function.
Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis.
TLDR
It is demonstrated that membrane-type 3 MMP, MT3-MMP, is expressed in mesenchymal tissues of the skeleton and in peri-skeletal soft connective tissue, and works as a major collagenolytic enzyme, enabling cartilage and bone cells to cleave high-density fibrillar collagen and modulate their resident matrix to make it permissive for proliferation and migration.
Membrane‐type 1 matrix metalloproteinase is required for normal alveolar development
TLDR
It is indicated that MT1‐MMP is required for normal lung development, as mice deficient in MMP‐3, 7, 9, or 12 develop a normal adult lung.
Characterization of a 140-kD avian cell surface antigen as a fibronectin-binding molecule
TLDR
Results indicate that the 140k complex can bind directly to fibronectin and is likely to be a fibronECTin receptor for chicken cells.
MT1‐MMP: A tethered collagenase
TLDR
It is demonstrated that growth and maintenance of the skeleton requires coordinated and simultaneous MT1‐MMP‐dependent remodeling of all soft tissue attachments (ligaments, tendons, joint capsules) and it is of interest to note that loss of a single catabolic function gives rise to profound impairment of a number of both anabolic and catabolic functions.
The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.
TLDR
Interspecies amino acid sequence comparison supports the importance of the LDV sequence, since it is completely conserved in the IIICS regions of human, rat, bovine, and avian fibronectins.
Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras.
TLDR
The results indicate that information contained in the beta 1, beta 3, or beta 5 integrin intracellular domain is sufficient to stimulate integrin-mediated tyrosine phosphorylation of specific intrACEllular proteins and that integrin extracellular and transmembrane domains are not required for inducing tyrosinesineosphorylation.
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