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- Publications
- Influence
Genomic dissection of population substructure of Han Chinese and its implication in association studies.
- S. Xu, Xianyong Yin, +21 authors L. Jin
- Biology, Medicine
- American journal of human genetics
- 11 December 2009
To date, most genome-wide association studies (GWAS) and studies of fine-scale population structure have been conducted primarily on Europeans. Han Chinese, the largest ethnic group in the world,… Expand
A genome-wide search for signals of high-altitude adaptation in Tibetans.
Genetic studies of Tibetans, an ethnic group with a long-lasting presence on the Tibetan Plateau which is known as the highest plateau in the world, may offer a unique opportunity to understand the… Expand
Charybdotoxin Binding in the IKs Pore Demonstrates Two MinK Subunits in Each Channel Complex
- H. Chen, L. A. Kim, S. Rajan, S. Xu, S. Goldstein
- Biology, Medicine
- Neuron
- 25 September 2003
I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer… Expand
The Y-chromosome landscape of the Philippines: extensive heterogeneity and varying genetic affinities of Negrito and non-Negrito groups
- F. Delfin, J. Salvador, +14 authors M. D. Ungria
- Biology, Medicine
- European Journal of Human Genetics
- 1 February 2011
The Philippines exhibits a rich diversity of people, languages, and culture, including so-called ‘Negrito’ groups that have for long fascinated anthropologists, yet little is known about their… Expand
Identification of Functional Mutations in GATA4 in Patients with Congenital Heart Disease
Congenital heart disease (CHD) is one of the most prevalent developmental anomalies and the leading cause of noninfectious morbidity and mortality in newborns. Despite its prevalence and clinical… Expand
The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B
In the past 50 years there have been considerable efforts to identify the cellular receptor of hepatitis B virus (HBV). Recently, in vitro evidence from several groups has shown that the… Expand
Analysis of genomic admixture in Uyghur and its implication in mapping strategy.
The Uyghur (UIG) population, settled in Xinjiang, China, is a population presenting a typical admixture of Eastern and Western anthropometric traits. We dissected its genomic structure at population… Expand
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.
- S. Xu, Jittima Weerachayaphorn, S. Cai, C. Soroka, J. Boyer
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 1 July 2010
Multidrug resistance protein 4 (MRP4; ABCC4) is an ATP binding cassette transporter that facilitates the excretion of bile salt conjugates and other conjugated steroids in hepatocytes and renal… Expand
Human Migration through Bottlenecks from Southeast Asia into East Asia during Last Glacial Maximum Revealed by Y Chromosomes
- Xiaoyun Cai, Zhendong Qin, +9 authors H. Li
- Geography, Medicine
- PloS one
- 31 August 2011
Molecular anthropological studies of the populations in and around East Asia have resulted in the discovery that most of the Y-chromosome lineages of East Asians came from Southeast Asia. However,… Expand