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Markers in the promoter region of interleukin-10 (IL-10) gene in myasthenia gravis: implications of diverse effects of IL-10 in the pathogenesis of the disease
TLDR
Novel genetic markers within IL-10 gene indicating different mechanisms forIL-10 involved in the disease are demonstrated, including 'high secretor' phenotype for IL-1beta TaqI polymorphism, which was found in Swedish myasthenia gravis patients and ethnically matched healthy individuals. Expand
No evidence for interleukin-4 gene conferring susceptibility to myasthenia gravis
TLDR
There were no associations between these polymorphisms and MG patients as a whole group or stratified by clinical and pathological parameters and genetic markers in MHC gene (TNF-alpha NcoI allele 2) and IL-1 gene (IL-1beta TaqI allele 1). Expand
Genetic association of Ctla-4 to myasthenia gravis with thymoma
TLDR
The results further advocate that MG is a polygenetic disease and suggest that co-stimulators such as CTLA-4 and CD28 might have an important role in the pathogenesis of the disease. Expand
Genetic association of Ctla-4 to myasthenia gravis with thymoma
TLDR
The results further advocate that MG is a polygenetic disease and suggest that co-stimulators such as CTLA-4 and CD28 might have an important role in the pathogenesis of the disease. Expand
Ginkgo biloba extract attenuates the disruption of pro-and anti-inflammatory T-cell balance in peripheral blood of arsenicosis patients
TLDR
Results indicated that exposure to arsenic is associated with immune-related problems, and a previously unknown mechanism showing that an imbalance of pro- and anti-inflammatory T cells is involved in the pathogenesis of arsenicosis is described. Expand
Correlation among CD4+CD25+ T Cell Frequency, CTLA-4 Expression Level, and Disease Progression in Patients with HIV/AIDS
TLDR
CTLA-4 expressed on CD4+CD25+ Treg cells can be a specific marker of the progression of HIV/AIDS, and the inhibitory receptor may play an important role in the regulation and pathogenesis of HIV /AIDS. Expand
Differential expression and significance of Foxp3, TGF-β1 and IL-2 in peripheral blood of patients with coal-burning arsenic poisoning
TLDR
Arsenic exposure can cause abnormal changes of Treg-specific transcription factor Foxp3 and related immune factors TGF-β1 and IL-2 in peripheral blood of patients, and it is suggested that Treg dysfunction may be related to arsenic poisoning. Expand