• Publications
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Solubility of androstenedione in lower alcohols
Abstract Androstenedione (AD) solubilities in methanol, ethanol, 2-propanol, and 1-butanol were measured from 277.65 K to 319.45 K with medium-throughput experiments. The results show that ADExpand
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Determination and correlation of solubility and solution thermodynamics of oxiracetam in three (alcohol + water) binary solvents
Abstract In this paper, we proposed a static analysis method to experimentally determine the (solid + liquid) equilibrium of racemic oxiracetam in (methanol + water), (ethanol + water) andExpand
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Caking of crystals: Characterization, mechanisms and prevention
Abstract Caking of crystals leads to a great deal of negative impact on the quality of products leading to extra cost to restore the products to its original state before caking. It is therefore anExpand
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Solubility of tridecanedioic acid in pure solvent systems: An experimental and computational study
Abstract Solubility has been extensively investigated by the phase equilibria approach at the mesoscale level, but its origin on the molecular and electronic levels is poorly understood. This studyExpand
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Solubility Correlation and Thermodynamic Analysis of Sorafenib Free Base and Sorafenib Tosylate in Monosolvents and Binary Solvent Mixtures
The solubility of sorafenib free base (SFB) and sorafenib tosylate (ST) in five monosolvents and binary solvents of 2-propanol + 1,4-dioxane was measured over the temperature ranged from 283.15 toExpand
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Novel Glutaric Acid Cocrystal Formation via Cogrinding and Solution Crystallization
An efficient and reliable approach to discover new pharmaceutical cocrystals in the early development stage is proposed and used to develop cocrystals of piracetam with some aliphatic diacids. A 1:1Expand
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Two novel cocrystals of lamotrigine with isomeric bipyridines and in situ monitoring of the cocrystallization
  • Shichao Du, Y. Wang, +7 authors J. Gong
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 15 December 2017
Abstract Crystal engineering strategy was applied to develop new solid forms of lamotrigine. Two novel cocrystals of lamotrigine forming with 4,4′‐bipyridine (2:1) and 2,2′‐bipyridine cocrystalExpand
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Solvent penetration mediated phase transformation for the preparation of aggregated particles with well-defined shape
We report here a unique method for the preparation of aggregated crystals with well-defined shape and size using a solvent penetration-mediated phase transformation. An unusually fast phaseExpand
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Transformations among the New Solid-State Forms of Clindamycin Phosphate
An experimental study is undertaken to establish a transformation screen for the solid-state forms of clindamycin phosphate. The experimental study results in six novel crystalline forms: twoExpand
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