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Severe impairment of T-cell responses to BNT162b2 immunization in patients with multiple myeloma

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Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation

In a multivariate analysis, obesity was identified as an independent risk factor for death (Hazard ratio 2.231; 95% CI 1.024 to 4.860) and further studies are needed to evaluate the reasons for the higher relapse rate causing higher mortality in obese patients.
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Frequence, Spectrum and Prognostic Impact of Additional Malignancies in Patients With Gastrointestinal Stromal Tumors1234

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p16 expression differentiates high-risk gastrointestinal stromal tumor and predicts poor outcome.

Gastrointestinal stromal tumors (GISTs) are characterized by alterations in genes involved in cell cycle regulation. Although p16 (INK4A) have been extensively investigated in GISTs, there are still…
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Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells

By concomitant stimulation of both death receptor systems IFNα/Smac mimetic combination treatment is an effective strategy to induce cell death in TNFα- or TRAIL-responsive cancers.
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[Growth of sporadic vestibular schwannomas correlates with Ki-67 proliferation index].

The determination of proliferation can serve as a further decision guidance during surgery of vestibular schwannoma, especially if tumor resection results in functional impairment of the facial nerve.
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The proteogenomic subtypes of acute myeloid leukemia.

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Bloodstream infections with vancomycin-resistant enterococci are associated with a decreased survival in patients with hematological diseases

The primary endpoint, overall survival at 30 days after BSI, was significantly lower in patients with VRE BSI compared to Patients with VSE BSI and it was found that VRE with an additional teicoplanin resistance showed a trend towards an even lower OS.
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Identification of BMP2 as an epigenetically silenced growth inhibitor in rhabdomyosarcoma.

Findings suggest that suppression of BMP2 by epigenetic silencing may play a critical role in the genesis of RMS, thereby providing a rationale for the development of a new treatment strategy for RMS.
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SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.

Overall, this study has uncovered the dependency landscape in BL, identified and validated SHMT2 as a drug target and revealed a mechanistic link between SH MT2 and the transcriptional master regulator TCF3, opening up new perspectives for innovative therapies.
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