Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia
- P. K. Raveendran Nair, S. Rodriguez, C. Ramachandran
- BiologyInternational Immunopharmacology
- 25 August 2004
Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues.
- Bhaskar Gopishetty, Jinge G. Zhu, D. Pei
- Chemistry, BiologyJournal of the American Chemical Society
- 28 January 2009
The 3-ketone intermediate was chemically synthesized and shown to be chemically and kinetically competent in the LuxS catalytic pathway, andstrate analogues halogenated at the C3 position of ribose were synthesised and reacted as time-dependent inhibitors of LuxS.
Isolation and characterization of an anticancer catechol compound from Semecarpus anacardium.
- P. Nair, S. Melnick, S. Wnuk, M. Rapp, E. Escalon, C. Ramachandran
- Biology, ChemistryJournal of Ethnopharmacology
- 21 April 2009
Synthesis and analysis of 1-octen-3-ol, the main flavour component of mushrooms.
- S. Wnuk, S. Kinastowski, E. Kamiński
- Chemistry, MedicineDie Nahrung
- 1983
To meet the demand for a flavour compound yielding a mushroom odour, a study was carried out on the possibility of obtaining 1-octen-3-ol synthetically and the compound obtained had its IR, 13C NMR spectra and GLC chromatogram identical with those of the standard.
Molecular mass growth through ring expansion in polycyclic aromatic hydrocarbons via radical–radical reactions
A mechanism through laboratory experiments and computations is presented revealing how the prototype PAH—naphthalene—can be efficiently formed via a rapid 1-indenyl radical—methyl radical reaction, providing a radical new view about the transformations of carbon in the authors' universe.
Strain Promoted Click Chemistry of 2- or 8-Azidopurine and 5-Azidopyrimidine Nucleosides and 8-Azidoadenosine Triphosphate with Cyclooctynes. Application to Living Cell Fluorescent Imaging.
- Jessica Zayas, Marie Annoual, S. Wnuk
- Chemistry, BiologyBioconjugate chemistry
- 2 July 2015
The novel triazole adducts at the 2- or 8- position of adenine or 5-position of uracil rings induce fluorescence properties which were used for direct imaging in MCF-7 cancer cells without the need for traditional fluorogenic reporters.
Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring.
- Venkata L A Malladi, Adam J. Sobczak, Tiffany M Meyer, D. Pei, S. Wnuk
- Biology, ChemistryBioorganic & Medicinal Chemistry
- 15 September 2011
Synthesis of the multisubstituted halogenated olefins via cross-coupling of dihaloalkenes with alkylzinc bromides.
- Daniela Andrei, S. Wnuk
- ChemistryJournal of Organic Chemistry
- 6 January 2006
[reaction: see text] The 1-fluoro-1-haloalkenes undergo Pd-catalyzed Negishi cross-couplings with primary alkylzinc bromides to give multisubstituted fluoroalkenes. The alkylation was trans-selective…
Targeting "hydrolytic" activity of the S-adenosyl-L-homocysteine hydrolase.
- S. Wnuk
- Chemistry, BiologyMini-Reviews in Medical Chemistry
- 31 August 2001
Dihalohomovinyl and haloacetylene analogues derived from adenosine as well 5'-S-allenyl-5'--thioadenosine derivative have been characterized as the first type II mechanism-based inhibitors of AdoHcy hydrolase that rely only on the "hydrolytic" activity.
Structure of the nitrogen-centered radical formed during inactivation of E. coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine-5'-diphosphate: trapping of the 3'-ketonucleotide.
- J. Fritscher, Erin Artin, J. Stubbe
- Chemistry, BiologyJournal of the American Chemical Society
- 10 May 2005
It was proposed that N* is also covalently attached to the nucleotide through either the oxygen of the 3'-OH (R-S-N*-O-R') or the 2-methylene-3-furanone, pyrophosphate, and uracil structure and provided evidence for the trapping of a 3'-ketonucleotide in the reduction process.
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