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Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia
The water solubility, high molecular mass, activation of lymphocytes especially NK cells, complement activation, Th1 pathway-associated cytokine profile, together with a low level of nitric oxide synthesis and absence of oxidative stress confer important immunoprotective potential to this novel α-d-glucan. Expand
Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues.
The 3-ketone intermediate was chemically synthesized and shown to be chemically and kinetically competent in the LuxS catalytic pathway, andstrate analogues halogenated at the C3 position of ribose were synthesised and reacted as time-dependent inhibitors of LuxS. Expand
Isolation and characterization of an anticancer catechol compound from Semecarpus anacardium.
SA-3C isolated from the kernel of Semecarpus anacardium can be developed as an important anticancer agent for single agent and/or multiagent cancer therapy. Expand
Synthesis and analysis of 1-octen-3-ol, the main flavour component of mushrooms.
To meet the demand for a flavour compound yielding a mushroom odour, a study was carried out on the possibility of obtaining 1-octen-3-ol synthetically and the compound obtained had its IR, 13C NMR spectra and GLC chromatogram identical with those of the standard. Expand
Targeting "hydrolytic" activity of the S-adenosyl-L-homocysteine hydrolase.
  • S. Wnuk
  • Chemistry, Medicine
  • Mini reviews in medicinal chemistry
  • 31 August 2001
Dihalohomovinyl and haloacetylene analogues derived from adenosine as well 5'-S-allenyl-5'--thioadenosine derivative have been characterized as the first type II mechanism-based inhibitors of AdoHcy hydrolase that rely only on the "hydrolytic" activity. Expand
Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position.
This work has synthesized several SRH analogues modified at the ribose C3 position as potential inhibitors of LuxS, finding that inversion of the C3 stereochemistry or substitution of fluorine for C3-OH resulted in slow-binding inhibitors of improved potency. Expand
S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit.
Treatment of the protected ribose or xylose 5-aldehyde with sulfonyl-stabilized fluorophosphonate gave (fluoro)vinyl sulfones, which acted as a competitive inhibitor of moderate potency in inhibition of Bacillus subtilis S-ribosylhomocysteinase. Expand
Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring.
The structure-activity relationship of the designed inhibitors highlights the importance of both the homocysteine and ribose moieties for high-affinity binding to LuxS active site. Expand
Strain Promoted Click Chemistry of 2- or 8-Azidopurine and 5-Azidopyrimidine Nucleosides and 8-Azidoadenosine Triphosphate with Cyclooctynes. Application to Living Cell Fluorescent Imaging.
The novel triazole adducts at the 2- or 8- position of adenine or 5-position of uracil rings induce fluorescence properties which were used for direct imaging in MCF-7 cancer cells without the need for traditional fluorogenic reporters. Expand
Synthesis of Purine and 7‐Deazapurine Nucleoside Analogues of 6‐N‐(4‐Nitrobenzyl)adenosine; Inhibition of Nucleoside Transport and Proliferation of Cancer Cells
The design and synthesis of novel tool compounds for the further study of hENT1 are reported here and type‐specific inhibition of cancer cell proliferation was observed at micromolar concentrations with the 4‐N‐(4‐nitrobenzyl) derivatives of sangivamycin and toyocamycin antibiotics. Expand