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Plasticity of Cultured Mesenchymal Stem Cells: Switch from Nestin‐Positive to Excitable Neuron‐Like Phenotype
Bone marrow mesenchymal stem cells (MSCs) can differentiate into several types of mesenchymal cells, including osteocytes, chondrocytes, and adipocytes, but, under appropriate experimentalExpand
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Regulation of neural markers nestin and GFAP expression by cultivated bone marrow stromal cells
Bone marrow stromal cells can differentiate into many types of mesenchymal cells, i.e. osteocyte, chondrocyte and adipocyte, but can also differentiate into non-mesenchymal cells, i.e. neural cellsExpand
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Astrocytic and neuronal fate of mesenchymal stem cells expressing nestin
Classically, bone marrow mesenchymal stem cells (MSC) differentiate in vivo or in vitro into osteocytes, chondrocytes, fibroblasts and adipocytes. Recently, it was reported by several groups that MSCExpand
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Mesenchymal stem cells and neural crest stem cells from adult bone marrow: characterization of their surprising similarities and differences
The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders.Expand
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α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity*♦
Background: α-Synuclein is known to undergo exchange between membrane and cytosolic compartments. Results: α-Synuclein interacts with GTP-bound Rab3a on synaptic vesicles, and its dissociation isExpand
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Stem cell factor and mesenchymal and neural stem cell transplantation in a rat model of Huntington's disease
Neural and mesenchymal stem cells have been proposed as alternative sources of cells for transplantation into the brain in neurodegenerative disorders. However, the endogenous factors controllingExpand
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Concise Review: Adult Mesenchymal Stem Cells, Adult Neural Crest Stem Cells, and Therapy of Neurological Pathologies: A State of Play
Adult stem cells are endowed with in vitro multilineage differentiation abilities and constitute an attractive autologous source of material for cell therapy in neurological disorders. With regard toExpand
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Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes*
Background: The majority of α-synuclein is phosphorylated at serine 129 in Lewy bodies. Results: The membrane association of PD-linked mutant α-synuclein, but not wild-type α-synuclein, was increasedExpand
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Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression.
Some synthetic ligands of the peripheral-type benzodiazepine receptor (PBR), an 18 kDa protein of the outer mitochondrial membrane, are cytotoxic for several tumor cell lines and arise as promisingExpand
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Concise Review: Spinal Cord Injuries: How Could Adult Mesenchymal and Neural Crest Stem Cells Take Up the Challenge?
Since several years, adult/perinatal mesenchymal and neural crest stem cells have been widely used to help experimental animal to recover from spinal cord injury. More interestingly, recent clinicalExpand
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