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Protein complexes of intermediate-sized filaments: melting of cytokeratin complexes in urea reveals different polypeptide separation characteristics.
TLDR
The data suggest that certain cytokeratin polypeptides are complementary and contain sequences that direct their association into specific complexes forming IF subunits, and that cytokeratins do not form complexes with vimentin, another type of IF protein. Expand
Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues.
TLDR
Individual cytokeratins provide tissue- or cell type-specific markers that are useful in the definition and identification of the relatedness or the origin of epithelial and carcinoma cells. Expand
Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific alpha-type actin.
TLDR
Vimentin has been demonstrated in a smooth muscle cell present in the body and it is proposed that the intermediate filament and actin composition of vascular smooth muscle cells reflects a differentiation pathway separate from that of other smoother muscle cells and may be related to special functions and pathological disorders of blood vessels. Expand
Antibodies to the major insoluble milk fat globule membrane-associated protein: specific location in apical regions of lactating epithelial cells
TLDR
Findings indicate that butyrophilin, which is constitutively secreted by surface budding in coordination with milk lipid production, is located at the apical surface and is not detected at basolateral surfaces, in endoplasmic reticulum, and in Golgi apparatus. Expand
Widespread occurrence of intermediate-sized filaments of the vimentin-type in cultured cells from diverse vertebrates.
TLDR
The data are consistent with the idea that most cells grown in culture contain intermediate-sized filaments of the vimentin type, irrespective of the state of differentiation of the cells from which they are derived, and suggest that the vimentsin molecule contains both sequences conserved during evolution and regions different in different vertebrate species. Expand
Formation of cytoskeletal elements during mouse embryogenesis. II. Epithelial differentiation and intermediate-sized filaments in early postimplantation embryos.
TLDR
It is concluded that early postimplantation embryonic development, up to mesoderm formation, is characterized by the exclusive presence, in both embryonic ectoderm and proximal endoderm, of differentiated epithelial cells containing desmosome-cytokeratin filament complexes and that other types of intermediate-sized filaments are not yet expressed. Expand
Use of fluorescence decay times of 8-ANS-protein complexes to study the conformational transitions in proteins which unfold through the molten globule state.
TLDR
The conformational transitions starting with the native protein, passing the molten globule state and finally approaching the unfolded state of proteins was investigated by means of fluorescence decay time measurements of the dye 8-anilinonaphthalene-1-sulphonic acid. Expand
Isolation and characterization of desmosome-associated tonofilaments from rat intestinal brush border
TLDR
The data indicate that structurally identical tonofilaments can be formed, in different types of cells, by different polypeptides of the cytokeratin family of proteins and that ton ofilaments of various epithelia display tissue- specific patterns of their protein subunits. Expand
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