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Beyond Bar and Line Graphs: Time for a New Data Presentation Paradigm
TLDR
A systematic review of research articles published in top physiology journals suggests that, as scientists, the authors urgently need to change their practices for presenting continuous data in small sample size studies.
Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer
TLDR
This study demonstrates the histotype-specific nature of immune infiltration and provides definitive evidence for a dose-response relationship between CD8+ TILs and HGSOC survival and suggests that understanding factors that drive infiltration will be the key to unraveling outcome heterogeneity in this cancer.
SNP interaction detection with Random Forests in high-dimensional genetic data
TLDR
While RF remains a promising data-mining technique that extends univariate methods to condition on multiple variables simultaneously, RF variable importance measures fail to detect interaction effects in high-dimensional data in the absence of a strong marginal component, and therefore may not be useful as a filter technique that allows for interactioneffects in genome-wide data.
Data visualization, bar naked: A free tool for creating interactive graphics
TLDR
A free, web-based tool for creating an interactive alternative to the bar graph and a tool to encourage exploration and critical evaluation of the data behind the summary statistics are introduced, which may be valuable for promoting transparency, reproducibility, and open science in basic biomedical research.
Auriculotherapy for pain management: a systematic review and meta-analysis of randomized controlled trials.
TLDR
Auriculotherapy may be effective for the treatment of a variety of types of pain, especially postoperative pain, however, a more accurate estimate of the effect will require further large, well-designed trials.
CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel
TLDR
Patients carrying CYP2C8*3 are more likely to achieve clinical complete response from neoadjuvant paclitaxel treatment, but may also be at increased risk of experiencing severe peripheral neurotoxicity.
Prevalence and correlates of DSM-5 eating disorders in patients with bipolar disorder.
TLDR
DS-5-defined BED and BN are common in BP patients, possibly more common than DSM-IV- defined BEDand BN, and associated with greater psychiatric and general medical illness burden.
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
TLDR
Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
Clinical phenotype of bipolar disorder with comorbid binge eating disorder.
TLDR
As the association of BED with greater psychiatric illness burden remained significant even after accounting for the effect of obesity, BP with BED may represent a clinically important sub-phenotype.
Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium
TLDR
SNPs in three lncRNAs that might be important targets for novel EOC therapies are identified, including YAP1- and WWTR1 (TAZ)-stimulated gene expression and high-density lipoprotein (HDL)-mediated lipid transport pathways were associated with PFS and OS, respectively, in the cohort who had standard chemotherapy.
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