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- Publications
- Influence
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
- Borbala Mifsud, Filipe Tavares-Cadete, +15 authors C. Osborne
- Biology, Medicine
- Nature Genetics
- 1 June 2015
Transcriptional control in large genomes often requires looping interactions between distal DNA elements, such as enhancers and target promoters. Current chromosome conformation capture techniques do… Expand
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
- B. Javierre, O. Burren, +37 authors Peter Fraser
- Biology, Medicine
- Cell
- 17 November 2016
Summary Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation. The vast majority of interactions are uncharted, constituting a major… Expand
FastQ Screen: A tool for multi-genome mapping and quality control.
- S. Wingett, S. Andrews
- Medicine
- F1000Research
- 2018
DNA sequencing analysis typically involves mapping reads to just one reference genome. Mapping against multiple genomes is necessary, however, when the genome of origin requires confirmation.… Expand
Cell-cycle dynamics of chromosomal organisation at single-cell resolution
- T. Nagano, Yaniv Lubling, +7 authors A. Tanay
- Biology, Medicine
- Nature
- 9 June 2017
Chromosomes in proliferating metazoan cells undergo marked structural metamorphoses every cell cycle, alternating between highly condensed mitotic structures that facilitate chromosome segregation,… Expand
CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data
- J. Cairns, P. Freire-Pritchett, +9 authors Mikhail Spivakov
- Biology, Medicine
- Genome Biology
- 15 June 2016
Capture Hi-C (CHi-C) is a method for profiling chromosomal interactions involving targeted regions of interest, such as gene promoters, globally and at high resolution. Signal detection in CHi-C data… Expand
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements.
- S. Schoenfelder, M. Furlan-Magaril, +21 authors Peter Fraser
- Biology, Medicine
- Genome research
- 1 April 2015
The mammalian genome harbors up to one million regulatory elements often located at great distances from their target genes. Long-range elements control genes through physical contact with promoters… Expand
HiCUP: pipeline for mapping and processing Hi-C data
- S. Wingett, Philip Ewels, +4 authors S. Andrews
- Biology, Medicine
- F1000Research
- 20 November 2015
HiCUP is a pipeline for processing sequence data generated by Hi-C and Capture Hi-C (CHi-C) experiments, which are techniques used to investigate three-dimensional genomic organisation. The pipeline… Expand
Global Reorganization of the Nuclear Landscape in Senescent Cells
- T. Chandra, Philip Ewels, +7 authors W. Reik
- Biology, Medicine
- Cell reports
- 29 January 2015
Summary Cellular senescence has been implicated in tumor suppression, development, and aging and is accompanied by large-scale chromatin rearrangements, forming senescence-associated heterochromatic… Expand
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
- S. Schoenfelder, R. Sugar, +19 authors S. Elderkin
- Biology, Medicine
- Nature Genetics
- 1 October 2015
The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC) pluripotency by silencing lineage-specifying developmental regulator genes. Emerging evidence suggests that Polycomb… Expand
Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C.
- Nicola H Dryden, Laura R Broome, +17 authors O. Fletcher
- Biology, Medicine
- Genome research
- 13 August 2014
Genome-wide association studies have identified more than 70 common variants that are associated with breast cancer risk. Most of these variants map to non-protein-coding regions and several map to… Expand