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Midline signalling is required for Pax gene regulation and patterning of the eyes.
- R. Macdonald, K. Barth, Q. Xu, N. Holder, I. Mikkola, S. Wilson
- Biology, Medicine
- 1 October 1995
The results suggest that a signal emanating from the midline, which is absent in cyclops mutant embryos, may be required to promote Pax2 and inhibit Pax6 expression in cells destined to form the optic stalks and thus may regulate the partitioning of the optic primordia into opticStalks and retinal tissue. Expand
Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain.
Results suggest a requirement of shh/vhh-1 protein for the spatial regulation of nk2.2 expression in zebrafish, which is expressed in a continuous narrow band of cells along a boundary zone demarcating the location at which two of the earliest nuclei in the brain differentiate. Expand
The development of a simple scaffold of axon tracts in the brain of the embryonic zebrafish, Brachydanio rerio.
At 1 day, the zebrafish brain is impressively simple, with a few small, well-separated tracts but by 2 days the brain is already considerably more complex, supporting the notion that other axons play a crucial role in the guidance of early central nervous system (CNS). Expand
A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon.
It is shown that mbl(-/-) embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1, which abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription. Expand
Asymmetry in the epithalamus of vertebrates
The epithalamus is a major subdivision of the diencephalon constituted by the habenular nuclei and pineal complex and Connectivity of the parapineal organ with the left habenula is not always coupled with asymmetries in ha benular size and/or neuronal organisation suggesting that, at least in some species, assignment of parapineAL and habenul asymmetry may be independent events. Expand
Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons.
- S. Guo, S. Wilson, S. Cooke, A. Chitnis, W. Driever, A. Rosenthal
- Biology, Medicine
- Developmental biology
- 15 April 1999
A genetic screen for mutations which affect the commitment and differentiation of catecholaminergic neurons in the zebrafish, Danio rerio reveals an underlying universal mechanism for the control of CA cell fates, which involve combinatorial usage of regulatory genes. Expand
Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon.
It is found that Ace is required for the development of midline structures in the forebrain in zebrafish embryos that lack functional Fgf8/Ace and it is shown that ace expression co-localises with anterior neural plate cells that have previously been shown to have forebrain patterning activity. Expand
The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain.
Results indicate that Noi is required in cells that line the pathways taken by optic and non-optic commissural axons for guidance across the midline of the diencephalon. Expand
Bmp activity establishes a gradient of positional information throughout the entire neural plate.
- K. Barth, Y. Kishimoto, K. Rohr, C. Seydler, S. Schulte-Merker, S. Wilson
- Biology, Medicine
- 15 November 1999
It is shown that Bmp activity is required for specification of cell fates around the margin of the entire neural plate, including forebrain regions that do not form neural crest, and Surprisingly, it is found that BMP activity is also required for patterning neurons at all DV levels of the CNS. Expand
Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish.
Observations indicate that a key consequence of the anteroposterior regionalisation of segments may be the induction of Eph and ephrin expression at segment interfaces and that Eph/ephrin signalling subsequently contributes to the formation of somite boundaries. Expand