Midline signalling is required for Pax gene regulation and patterning of the eyes.
- R. Macdonald, K. Barth, Q. Xu, N. Holder, I. Mikkola, S. Wilson
- 1 October 1995
Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain.
Results suggest a requirement of shh/vhh-1 protein for the spatial regulation of nk2.2 expression in zebrafish, which is expressed in a continuous narrow band of cells along a boundary zone demarcating the location at which two of the earliest nuclei in the brain differentiate.
A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon.
- C. Heisenberg, C. Houart, D. Stemple
- BiologyGenes & Development
- 1 June 2001
It is shown that mbl(-/-) embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1, which abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription.
The development of a simple scaffold of axon tracts in the brain of the embryonic zebrafish, Brachydanio rerio.
- S. Wilson, L. S. Ross, T. Parrett, S. Easter
At 1 day, the zebrafish brain is impressively simple, with a few small, well-separated tracts but by 2 days the brain is already considerably more complex, supporting the notion that other axons play a crucial role in the guidance of early central nervous system (CNS).
Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons.
- S. Guo, S. Wilson, S. Cooke, A. Chitnis, W. Driever, A. Rosenthal
- BiologyDevelopmental Biology
- 15 April 1999
A genetic screen for mutations which affect the commitment and differentiation of catecholaminergic neurons in the zebrafish, Danio rerio reveals an underlying universal mechanism for the control of CA cell fates, which involve combinatorial usage of regulatory genes.
Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon.
- S. Shanmugalingam, C. Houart, S. Wilson
- 15 June 2000
It is found that Ace is required for the development of midline structures in the forebrain in zebrafish embryos that lack functional Fgf8/Ace and it is shown that ace expression co-localises with anterior neural plate cells that have previously been shown to have forebrain patterning activity.
Bmp activity establishes a gradient of positional information throughout the entire neural plate.
- K. Barth, Y. Kishimoto, K. Rohr, C. Seydler, S. Schulte-Merker, S. Wilson
- 15 November 1999
It is shown that Bmp activity is required for specification of cell fates around the margin of the entire neural plate, including forebrain regions that do not form neural crest, and Surprisingly, it is found that BMP activity is also required for patterning neurons at all DV levels of the CNS.
The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain.
- R. Macdonald, J. Scholes, S. Wilson
- 15 June 1997
Results indicate that Noi is required in cells that line the pathways taken by optic and non-optic commissural axons for guidance across the midline of the diencephalon.
Programmed cell death in zebrafish rohon beard neurons is influenced by TrkC1/NT-3 signaling.
- J. Williams, A. Barrios, C. Gatchalian, L. Rubin, S. Wilson, N. Holder
- BiologyDevelopmental Biology
- 15 October 2000
It is shown that the timing of RB cell death correlates with reduced expression of trkC1, the receptor for neurotrophin NT-3, but not with the appearance of DRG, which differentiate only after most RB cells die.
Antibodies against Pax6 immunostain amacrine and ganglion cells and neuronal progenitors, but not rod precursors, in the normal and regenerating retina of the goldfish.
- P. Hitchcock, R. Macdonald, J. T. Vanderyt, S. Wilson
- BiologyJournal of Neurobiology
- 1 March 1996
The results of this study document the identity of pax6-expressing cells in the mature retina and demonstrate that in the goldfish pX6 is expressed in neuronal progenitors during both retinal growth and regeneration.