Mining DNA methylation alterations towards a classification of placental pathologies
- S. Wilson, K. Leavey, B. Cox, W. Robinson
- MedicineHuman Molecular Genetics
- 30 October 2017
Despite large changes observed in EOPE, there were challenges in reproducing genome-wide DNAm hits that are discussed, and DNAm profiling may provide an independent tool to refine clinical/pathological diagnoses into subgroups with more uniform pathology.
Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels
- Yunsung Lee, S. Choufani, S. Horvath
- 24 June 2019
It is shown that epigenetic clocks derived from cord blood or other tissues do not accurately estimate gestational age in placental samples, and placental clocks closely track fetal age during development and may have interesting applications.
Number of Children and Telomere Length in Women: A Prospective, Longitudinal Evaluation
- C. Barha, C. Hanna, P. Nepomnaschy
- BiologyPLoS ONE
- 5 January 2016
Investigation of the relationship between the number of surviving children born to a woman and telomere length over 13 years in a group of 75 Kaqchikel Mayan women found women who had fewer children exhibited shorter TLs than those who had more children, contrary to LHT's prediction.
Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia
- K. Leavey, S. Wilson, S. Bainbridge, W. Robinson, B. Cox
- BiologyClinical Epigenetics
- 2 March 2018
DNA methylation alterations underlying a portion of the transcriptional development of “canonical” PE in cluster 2 and “immunological”PE in cluster 3 are established, however, a significant number of the observed methylation changes were not associated with corresponding changes in gene expression, indicating that alternate methods of gene regulation will need to be explored.
Utility of DNA methylation to assess placental health.
- S. Wilson, W. Robinson
- Biology, MedicinePlacenta
- 7 November 2017
Child mortality, hypothalamic-pituitary-adrenal axis activity and cellular aging in mothers
- C. Barha, K. Salvante, P. Nepomnaschy
- Biology, MedicinePLoS ONE
- 25 May 2017
The results are consistent with the hypothesis that traumatic events can influence cellular aging and that HPAA activity may play a mediatory role and future large-scale longitudinal studies are necessary to confirm the results and further explore the role of the HPAA in cellular aging.
Epigenetic Modifications in the Human Placenta
- W. Robinson, M. Peñaherrera, Chaini Konwar, V. Yuan, S. Wilson
- Biology, MedicineHuman Reproductive and Prenatal Genetics
Detecting somatic mosaicism: considerations and clinical implications
Somatic mosaicism is defined with a brief overview of its main mechanisms in concrete clinical examples, the impact of next‐generation sequencing technologies in its detection is discussed, and the clinical implications associated with a discovery in the clinic are expanded.
Placental telomere length decline with gestational age differs by sex and TERT, DNMT1, and DNMT3A DNA methylation.
- S. Wilson, Yao Liu, W. Robinson
- Biology, MedicinePlacenta
- 1 December 2016
DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births
- Chaini Konwar, E. Price, Li Wang, S. Wilson, J. Terry, W. Robinson
- Medicine, BiologyEpigenetics & Chromatin
- 29 October 2018
The authors' results suggest that aCA-associated placentas showed altered DNAm signatures that were not observed in the absence of aCA, which is consistent with the activation of the innate immune response in the placenta and/or reflect increase in neutrophils as a response to inflammation.