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The Genetic Structure and History of Africans and African Americans
A detailed genetic analysis of most major groups of African populations is provided, suggesting that Africans represent 14 ancestral populations that correlate with self-described ethnicity and shared cultural and/or linguistic properties.
A high-density admixture map for disease gene discovery in african americans.
This map provides a practical and powerful tool, which is freely available without restriction, for screening for disease genes in African American patient cohorts, and is especially appropriate for those diseases that differ in incidence between the parental African and European populations.
Genome-wide patterns of population structure and admixture in West Africans and African Americans
- K. Bryc, A. Auton, C. Bustamante
- BiologyProceedings of the National Academy of Sciences
- 22 December 2009
Quantifying patterns of population structure in Africans and African Americans illuminates the history of human populations and is critical for undertaking medical genomic studies on a global scale.…
Haplotype Diversity and Linkage Disequilibrium at Human G6PD: Recent Origin of Alleles That Confer Malarial Resistance
The hypothesis that malaria has had a major impact on humans only since the introduction of agriculture within the past 10,000 years is supported and the locus of “A−” and ”Med” mutations provides a striking example of the signature of selection on the human genome.
Bioinformatics challenges for genome-wide association studies
It is argued here that bioinformatics has an important role to play in addressing the complexity of the underlying genetic basis of common human diseases as well as those GWAS challenges that will require computational methods.
Genetic analysis of African populations: human evolution and complex disease
Africa is one of the most ethnically and genetically diverse regions of the world. It is thought to be the ancestral homeland of all modern humans, and is the homeland of millions of people of the…
G protein-coupled receptor kinase 4 gene variants in human essential hypertension
- R. Felder, H. Sanada, P. Jose
- Biology, MedicineProceedings of the National Academy of Sciences…
- 19 March 2002
Findings provide a mechanism for the D1 receptor coupling defect in the kidney and may explain the inability of the kidney to properly excrete sodium in genetic hypertension.
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction
The results suggest that balanced accuracy should be used instead of accuracy for the MDR analysis of epistasis in imbalanced datasets.
Epistasis and its implications for personal genetics.
A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry
A meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals ofAfrican ancestry provides strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.