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DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis
TLDR
DRAM (damage-regulated autophagy modulator), a p53 target gene encoding a lysosomal protein that induces macroautophagy, is described as an effector of p53-mediated death and its relationship to p53 function and damage-induced programmed cell death is highlighted. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Cdc42–MRCK and Rho–ROCK signalling cooperate in myosin phosphorylation and cell invasion
TLDR
It is shown that contractility necessary for elongated morphology and invasion can be generated by Cdc42–MRCK signalling, which mediates myosin-dependent cell motility and highlight convergence between Rho and CDC42 signalling. Expand
PUMA and Bax-induced Autophagy Contributes to Apoptosis
TLDR
Surprisingly, inhibition of PUMA or Bax-induced autophagy dampens the apoptotic response, suggesting that under some circumstances the selective targeting of mitochondria for autphagy can enhance apoptosis. Expand
TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-κB Signalling
TLDR
It is demonstrated that the xenophagy-associated kinase TBK1 drives basal autophagy, consistent with its known requirement in K-Ras-dependent NSCLC proliferation, and proposed that this TBK 1-dependent mechanism for NF-κB signalling contributes to autophagic addiction in K.Ras driven NSCLCs. Expand
CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis
TLDR
CCPG1, an ER-resident protein with no known physiological role, is identified as a non-canonical cargo receptor that directly binds to core autophagy proteins via an LIR motif to mammalian ATG8 proteins and, independently and via a discrete motif, to FIP200. Expand
DRAM Links Autophagy to p53 and Programmed Cell Death
TLDR
DRAM is a lysosomal protein that is not only critical for the ability of p53 to induce autophagy, but also for p53’s ability to induce programmed cell death – a facet of p 53 considered central to its tumor suppressive effects. Expand
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling
TLDR
C-Cbl-mediated autophagic targeting of active Src can occur in cancer cells to maintain viability when flux through the integrin/Src/FAK pathway is disrupted, exposing a previously unrecognized cancer cell vulnerability that may provide a new therapeutic opportunity. Expand
ER‐phagy: shaping up and destressing the endoplasmic reticulum
TLDR
A perspective on established views of selective autophagy are provided, comparing these with emerging mechanisms of ER‐phagy and related processes to provide a perspective on the function of the ER and the cell, both in normal physiology and when dysregulated within disease settings. Expand
Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy
TLDR
Analysis of DRAM-related proteins is described which reveals evolutionary conservation and divergence ofDRAM’s role in autophagy and that additional human proteins have more recently evolved which, while potentially sharing some similarities to DRAM function, may not be as intrinsically connected toAutophagy regulation. Expand
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