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Pharmacogenetics of pemetrexed combination therapy in lung cancer: pathway analysis reveals novel toxicity associations
Identification of polymorphisms that influence pemetrexed tolerability could lead to individualised treatment regimens and improve quality of life. Twenty-eight polymorphisms within eleven candidateExpand
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Clinico-Epidemiological Patterns of Cutaneous Leishmaniasis Patients Attending the Anuradhapura Teaching Hospital, Sri Lanka
Cutaneous leishmaniasis (CL) caused by Leishmania donovani is an endemic vector-borne disease in Sri Lanka. Over 2,500 cases have been reported since 2000 and the number of CL cases has dramaticallyExpand
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Human ocular dirofilariasis due to Dirofilaria repens in Sri Lanka.
OBJECTIVE To identify worms obtained from patients with eye lesions and to describe the demographic factors of patients with ocular dirofilariasis. METHODS A retrospective descriptive study wasExpand
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Morphological and molecular studies on Sri Lankan Leishmania
Cutaneous leishmaniasis (CL) is an emerging disease in Sri Lanka, more than 400 cases having been reported since 2001. However, the morphology and taxonomic status of the Sri Lankan strain ofExpand
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Assessment of intralesional cytokine profile of cutaneous leishmaniasis caused by Leishmania donovani in Sri Lanka
BackgroundCytokines play a vital role in the host immune response to infection by initiating the healing process and/or accelerating the progression of the disease in cutaneous leishmaniasis (CL).Expand
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Prevalence and associated factors of Enterobius vermicularis infection in children from a poor urban community in Sri Lanka: a cross-sectional study
Background: Enterobiasis (pin worm infection) is caused by Enterobius vermicularis ( E. vermicularis ). According to World Health Organization, over a billion people are infected worldwide. A crossExpand
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Posterior Fossa Decompression in Shunt‐Treated Hydrocephalic Children
The authors report a series of 14 cases who underwent posterior fossa decompression for complications arising after hydrocephalus was treated by a shunt procedure. The findings and results areExpand
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Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model.
OBJECTIVE To investigate the potential role of fresh Carica papaya (C. papaya) leaf extract on haematological and biochemical parameters and toxicological changes in a murine model. METHODS InExpand
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Arginine kinase in Toxocara canis: Exon-intron organization, functional analysis of site-directed mutants and evaluation of putative enzyme inhibitors.
OBJECTIVES To determine exon/intron organization of the Toxocara canis (T. canis) AK (TCAK) and to test green and black tea and several other chemicals against the activity of recombinant TCAK in theExpand
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Insight into genetic diversity of Mycobacterium tuberculosis in Kandy, Sri Lanka reveals predominance of the Euro-American lineage.
OBJECTIVE Sri Lanka is a country where the molecular epidemiology of Mycobacterium tuberculosis (MTB) is poorly explored. Therefore, this study was performed to identify circulating lineages/subExpand
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