• Publications
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Novel real‐time R‐wave detection algorithm based on the vectorcardiogram for accurate gated magnetic resonance acquisitions
The VCG of subjects exposed to a strong magnetic field can be use to separate the magnetohydrodynamic artifact and the actual R‐wave, and markedly improves the trigger accuracy in gated magnetic resonance scans. Expand
Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis.
Homing of melanoma exosomes to sentinel lymph nodes imposes synchronized molecular signals that effect melanoma cell recruitment, extracellular matrix deposition, and vascular proliferation in the lymph nodes. Expand
Practical Value of Cardiac Magnetic Resonance Imaging for Clinical Quantification of Aortic Valve Stenosis: Comparison With Echocardiography
The reliability of velocity-encoded CMR is defined as a routine method for quantifying stenotic aortic valve area, to compare this method with the accepted standard, and to evaluate its reproducibility. Expand
Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms.
It is demonstrated that medial SMC density is significantly decreased in human AAA tissues associated with evidence of SMC apoptosis and increased production of p53, a potential mediator of cell cycle arrest and programmed cell death. Expand
Quantification of in‐plane motion of the coronary arteries during the cardiac cycle: Implications for acquisition window duration for MR flow quantification
Estimation of the resulting vessel blurring was calculated, showing that the duration of the acquisition window for high spatial resolution coronary flow acquisitions should be less than 25 to 120 msec, depending on the specific coronary artery studied. Expand
Remodeling of cardiac fiber structure after infarction in rats quantified with diffusion tensor MRI.
The results of this study suggest that DTMRI may provide a valuable tool for defining structural remodeling in diseased myocardium at the cellular and tissue level. Expand
Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI.
  • Junjie Chen, W. Liu, +5 authors Xin Yu
  • Materials Science, Medicine
  • American journal of physiology. Heart and…
  • 1 November 2005
It is shown for the first time that geometric changes in both sheet and fiber orientation provide a substantial mechanism for radial wall thickening independent of active components due to myofiber shortening. Expand
Novel MRI Contrast Agent for Molecular Imaging of Fibrin: Implications for Detecting Vulnerable Plaques
Fibrin clots targeted in vitro with paramagnetic nanoparticles presented a highly detectable, homogeneous T1-weighted contrast enhancement that improved with increasing gadolinium level, suggesting that molecular imaging of fibrin-targeted param magnetic nanoparticles can provide sensitive detection and localization offibrin. Expand
Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.
It is suggested that matrilysin, specifically expressed in atherosclerotic lesions, could cleave structural proteoglycans and other matrix components, potentially leading to separation of caps and shoulders from lipid cores. Expand
Nanotechnological applications in medicine.
Highlighting clinically available and preclinical applications, this review explores the opportunities and issues surrounding nanomedicine. Expand