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Thrombin‐inhibiting perfluorocarbon nanoparticles provide a novel strategy for the treatment and magnetic resonance imaging of acute thrombosis
Summary.  Background: As a regulator of the penultimate step in the coagulation cascade, thrombin represents a principal target of direct and specific anticoagulants. Objective: A potent thrombinExpand
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High-frequency ultrasound detection of the temporal evolution of protein cross linking in myocardial tissue
The progressive increase in stiffening of the myocardium associated with the aging process and abetted by comorbid conditions such as diabetes may be linked to an excessive number of collagen crossExpand
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Characterization of digital waveforms using thermodynamic analogs: applications to detection of materials defects
We describe characterization of digital signals using analogs of thermodynamic quantities: the topological entropy, Shannon entropy, thermodynamic energy, partition function, specific heat atExpand
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Improvements in the ultrasonic contrast of targeted perfluorocarbon nanoparticles using an acoustic transmission line model
  • J. Marsh, C.S. Hall, +4 authors G. Lanza
  • Materials Science, Medicine
  • IEEE Transactions on Ultrasonics, Ferroelectrics…
  • 7 August 2002
Targeted acoustic contrast agents offer the potential for sensitive ultrasonic detection of pathologic tissues. We have previously reported the development of a ligand-targeted, lipid-encapsulated,Expand
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Characterization of digital waveforms using thermodynamic analogs: detection of contrast-targeted tissue in vivo
We describe characterization of backscatter from tumor tissue targeted with a nanoparticle-based ultrasound contrast agent in vivo using analogs of thermodynamic quantities. We apply these waveformExpand
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Sensitive Ultrasonic Delineation of Steroid Treatment in Living Dystrophic Mice with Energy-Based and Entropy-Based Radio Frequency Signal Processing
Duchenne muscular dystrophy is a severe wasting disease, involving replacement of necrotic muscle tissue by fibrous material and fatty infiltrates. One primary animal model of this human disease isExpand
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Ultrasonic molecular imaging of primordial angiogenic vessels in rabbit and mouse models with /spl alpha//sub v//spl beta//sub 3/ -integrin targeted nanoparticles using information-theoretic signal
The objective of this study was to assess the feasibility of image-based identification of nanoparticle targeted angiogenic neovasculature using backscattered ultrasound in several frequency rangesExpand
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Ultrasonic molecular imaging of primordial angiogenic vessels in the papilloma virus transgenic mouse with αvβ3-integrin targeted nanoparticles using Renyi entropy-based signal detection
Previously we reported on an entropy-based signal receiver and demonstrated that, in certain settings, it was more sensitive to subtle changes in scattering architecture than conventionalExpand
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Quantitative real-time imaging of myocardium based on ultrasonic integrated backscatter
The integrated backscatter calculation over the full, two-dimensional echocardiographic sector is implemented to produce images from closed-chest dogs. Expand
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A Real-Time Integrated Backscatter Measurement System for Quantitative Cardiac Tissue Characterization
Abstmct-To quantify integrated backscatter of ultrasound for realtime tissue characterization of myocardium in vivo an analog system that is used in conjunction with a two-dimensionaliM-modeExpand
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