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Pharmacokinetics, Safety, and Tolerability of Cefiderocol, a Novel Siderophore Cephalosporin for Gram-Negative Bacteria, in Healthy Subjects
TLDR
There was little accumulation of Cmax and AUC by dosing q8h, and the PK of cefiderocol did not change with multiple dosing, which indicates that single and multiple intravenous doses of ceciderocol are well tolerated in healthy subjects and exhibit linear PK at doses up to 2,000 mg.
In vitro antibacterial properties of BRL 36650, a novel 6 alpha-substituted penicillin
BRL 36650 is a new type of penicillin in which a formamido group has been introduced into the 6 alpha-position of the nucleus. The compound is highly active against aerobic gram-negative bacteria and
The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN
TLDR
Crystal structures of oxidised E. coli NfsA in the presence of several ligands, including the antibiotic nitrofurantoin are presented, showing that a mobile loop in the free protein forms a phosphate-binding pocket within the active site, likely to also occur with the natural cofactor.
InVitro Antibacterial Properties ofBRL 36650, a Novel6ac- Substituted Penicillin
strains, and showed a similar level ofactivity tomoxalactam, aztreonam, andthethird-generation cephalosporins cefotaxime andceftazidime. Against Pseudomonas aeruginosa andother Pseudomonas species,